Barbara Füzi, BSc MSc


Thesis title: "Analyzing and modeling pathways related to hepato- and/or neurotoxicity"

Thesis outline: The aim of my Doctoral Project is to find possible target proteins and biological processes for explaining and modelling hepatotoxic events triggered by pharmaceutically relevant compounds. With this knowledge, potential drugs could be tested for the identified off-targets and pathways early on in the drug discovery pipeline and they can be modified with the aim of avoiding the unwanted toxic event. The possible results can be used as a basis for understanding drug-induced toxicity of the liver. After deeper investigation and analysis, the findings are going to be used as a base for in silico toxicity modelling.

Supervisor & Co-Mentor: Gerhard F. Ecker