Ass.-Prof. Mag. Dr. Sophia Khom-Steinkellner
Sophia Khom-Steinkellner
41 - 60 out of 60
Luger D, Poli G, Wieder M, Stadler M, Ke S, Ernst M et al. Identification of the putative binding pocket of valerenic acid on GABAA receptors using docking studies and site-directed mutagenesis. British Journal of Pharmacology. 2015 Nov;172(22):5403-5413. doi: 10.1111/bph.13329, 10.1111/bph.13329

Wimmer L, Schönbauer D, Pakfeifer P, Schöffmann A, Khom S, Hering S et al. Developing piperine towards TRPV1 and GABAA receptor ligands - synthesis of piperine analogs via Heck-coupling of conjugated dienes. Organic & Biomolecular Chemistry. 2015 Jan 28;13(4):990-994. doi: 10.1039/c4ob02242d

Strommer B, Khom S, Kastenberger I, Cicek SS, Stuppner H, Schwarzer C et al. A Cycloartane Glycoside Derived from Actaea racemosa L. Modulates GABA(A) Receptors and Induces Pronounced Sedation in Mice. Journal of Pharmacology and Experimental Therapeutics. 2014 Nov;351(2):234-242. doi: 10.1124/jpet.114.218024

Hintersteiner J, Haider M, Luger D, Schwarzer C, Reznicek G, Jäger W et al. Esters of valerenic acid as potential prodrugs. European Journal of Pharmacology. 2014 Jul 15;735(1):123-131. doi: 10.1016/j.ejphar.2014.03.019

Schöffmann A, Wimmer L, Goldmann D, Khom S, Hintersteiner J, Baburin I et al. Efficient modulation of γ-aminobutyric acid type A receptors by piperine derivatives. Journal of Medicinal Chemistry. 2014 Jul 10;57(13):5602-5619. doi: 10.1021/jm5002277

Khom S, Strommer B, Schöffmann A, Hintersteiner J, Baburin I, Erker T et al. GABA(A) receptor modulation by piperine and a non-TRPV1 activating derivative. Biochemical Pharmacology. 2013 Jun 15;85(12):1827-1836. doi: 10.1016/j.bcp.2013.04.017

Singhuber J, Baburin I, Khom S, Zehl M, Urban E, Hering S et al. GABA(A) receptor modulators from the Chinese herbal drug Junci Medulla--the pith of Juncus effusus. Planta Medica: natural products and medicinal plant research. 2012 Mar;78(5):455-458. doi: 10.1055/s-0031-1298174

Cicek S, Khom S, Taferner B, Hering S, Stuppner H. Bioactivity-guided Isolation of GABA(A) Receptor Modulating Constituents from the Rhizome of Actaea racemosa. Planta Medica: natural products and medicinal plant research. 2011 Aug;77(12):1250-1251.

Zaugg J, Khom S, Eigenmann D, Baburin I, Hamburger M, Hering S. Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice. Journal of Natural Products. 2011;74(8):1764-1772. doi: 10.1021/np200317p

Cicek SS, Khom S, Taferner B, Hering S, Stuppner H. Bioactivity-guided isolation of GABA(A) receptor modulating constituents from the rhizomes of Actaea racemosa. Journal of Natural Products. 2010;73(12):2024-2028. doi: 10.1021/np100479w


Khom S, Strommer B, Ramharter J, Schwarz T, Schwarzer C, Erker T et al. Valerenic acid derivatives as novel subunit-selective GABA(A) receptor ligands - in vitro and in vivo characterization. British Journal of Pharmacology. 2010;161(1):65-78. doi: 10.1111/j.1476-5381.2010.00865.x



Trauner G, Khom S, Baburin I, Benedek B, Hering S, Kopp B. Modulation of GABAA Receptors by Valerian Extracts is related to the Content of Valerenic Acid. Planta Medica: natural products and medicinal plant research. 2008;74(1):19-24.


Brattstroem A, Baburin I, Khom S, Hering S, Koetter U. Valerian extract modulates the GABA(A)-action on its receptors. Planta Medica: natural products and medicinal plant research. 2006 Sept;72(11):1049-1049.

Khom S, Baburin I, Timin E, Hohaus A, Sieghart W, Hering S. Pharmacological properties of GABAA receptors containing gamma1 subunitsS. Molecular Pharmacology. 2006;69(2):640-649. doi: 10.1124/mol.105.017236

Baburin I, Beyl S, Khom S, Hering S. Automated drug screening of ligand- and voltage-gated ion channels on Xenopus Oocytes. Pharmacology. 2005;75(4):196-196.

Khom S, Baburin I, Timin E, Hohaus A, Sieghart W, Hering S. Pharmacological properties of GABA(A) receptors containing gamma1 Subunits. Pharmacology. 2005;75(4):195-195.

41 - 60 out of 60

Glucocorticoid regulation of GABA signaling in the central amygdala in alcohol use disorder

Khom-Steinkellner, S. (Speaker)

26 Jun 2024

Activity: Talks and presentationsTalk or oral contributionScience to Science



Mifepristone decreases GABA transmission in the central nucleus of the amygdala –role of alcohol history and sex

Khom-Steinkellner, S. (Speaker)

22 Jun 2021

Activity: Talks and presentationsTalk or oral contributionScience to Science


Aberrant central amygdala Substance P/Neurokinin 1 receptor signaling in alcohol dependence

Khom-Steinkellner, S. (Speaker)

21 Sept 201924 Sept 2019

Activity: Talks and presentationsTalk or oral contributionScience to Science


5 years of Screeing Tool : n automated medium throughput fast oocyte perfusion system

Khom, S. (Contributor)

20 Feb 2010

Activity: Talks and presentationsTalk or oral contributionOther


GABBAA-Receptors: Potential target for various natural products.

Khom, S. (Speaker)

10 Dec 2007

Activity: Talks and presentationsTalk or oral contributionOther


Benzodiazepines eliminate gamma subunit mediated suppression of GABA sensitivity of GABAA receptors

Khom, S. (Contributor)

3 Nov 2007

Activity: Talks and presentationsTalk or oral contributionOther


HPLC-based Activity Profiling of Plant and Fungal Extracts for GABAA Receptor Ligands using a Functional Assay with Xenopus Oocytes

Khom, S. (Speaker)

2 Sept 2007

Activity: Talks and presentationsTalk or oral contributionOther


Mutations in the GABA_A gamma2 subunit.

Khom, S. (Speaker)

10 Jan 2007

Activity: Talks and presentationsTalk or oral contributionOther



Pharmacological properties of GABAA- receptors containing gamma1 subunits

Khom, S. (Speaker)

24 Nov 2005

Activity: Talks and presentationsTalk or oral contributionOther


Role of SOX6 in parkinsonism and neurodevelopmental disease

Steinkellner, T. (Co-Lead) & Khom-Steinkellner, S. (Project Lead)

Project: Research funding


Becoming bilingual through transmitter co-release

Khom-Steinkellner, S. (Project Lead)

3/10/222/10/25

Project: Research funding


Department of Pharmaceutical Sciences

Josef-Holaubek-Platz 2 (UZA II)
1090 Wien
Room: 2E360

T: +43-1-4277-55035

sophia.khom-steinkellner@univie.ac.at