Assoz. Prof. Dr. Ulrich Lächelt
T: +43-1-4277-55404
21 - 40 out of 41
Lächelt U, Ludwig T. Neue Wirkstoff- und Gen-Delivery-Systeme. Laborjournal. 2022 Oct 7.

Huo T, Zhang X, Qian M, Nie H, Liang D, Lin C et al. A Space-Time Conversion Vehicle for Programmed Multi-Drugs Delivery into Pancreatic Tumor to Overcome Matrix and Reflux Barriers. Advanced science. 2022 Jul;9(20):2200608. doi: 10.1002/advs.202200608

Capelôa L, Yazdi M, Zhang H, Chen X, Nie Y, Wagner E et al. Cross-Linkable Polyion Complex Micelles from Polypept(o)ide-Based ABC-Triblock Copolymers for siRNA Delivery. Macromolecular Rapid Communications. 2022 Jun;43(12):2100698. Epub 2021 Dec 30. doi: 10.1002/marc.202100698

Andreo J, Ettlinger R, Zaremba O, Peña Q, Lächelt U, de Luis RF et al. Reticular Nanoscience: Bottom-Up Assembly Nanotechnology. Journal of the American Chemical Society. 2022 Apr 7;144(17):7531-7550. Epub 2022 Apr 7. doi: 10.1021/jacs.1c11507

Lin Y, Wagner E, Lächelt U. Non-viral delivery of the CRISPR/Cas system: DNA versus RNA versus RNP. Biomaterials Science. 2022 Jan 25;10(5):1166-1192. doi: 10.1039/d1bm01658j

Ettlinger R, Lächelt U, Gref R, Horcajada P, Lammers T, Serre C et al. Toxicity of metal–organic framework nanoparticles: from essential analyses to potential applications. Chemical Society Reviews. 2022 Jan 5;51(2):464-484. 51. doi: 10.1039/D1CS00918D

Krhač Levačić A, Berger S, Müller J, Wegner A, Lächelt U, Dohmen C et al. Dynamic mRNA polyplexes benefit from bioreducible cleavage sites for in vitro and in vivo transfer. Journal of Controlled Release. 2021 Nov 10;339:27-40. doi: 10.1016/j.jconrel.2021.09.016

Freund R, Zaremba O, Arnauts G, Ameloot R, Skorupskii G, Dincă M et al. The Current Status of MOF and COF Applications. Angewandte Chemie (International ed. in English). 2021 Nov 2;60(45):23975-24001. doi: 10.1002/anie.202106259

Kamenac A, Schilberth FL, Wagner E, Wixforth A, Lächelt U, Westerhausen C. Transient Permeabilization of Living Cells: Combining Shear Flow and Acoustofluidic Trapping for the Facilitated Uptake of Molecules. Processes. 2021 May;9(6):913. doi: 10.3390/pr9060913

Loy DM, Krzysztoń R, Lächelt U, Rädler JO, Wagner E. Controlling nanoparticle formulation: A low-budget prototype for the automation of a microfluidic platform. Processes. 2021;9(1):1-16. 129. doi: 10.3390/pr9010129

Ploetz E, Engelke H, Lächelt U, Wuttke S. The Chemistry of Reticular Framework Nanoparticles: MOF, ZIF, and COF Materials. Advanced Functional Materials. 2020 Oct 1;30(41):1909062. doi: 10.1002/adfm.201909062

Hirschle P, Hirschle C, Böll K, Döblinger M, Höhn M, Tuffnell JM et al. Tuning the Morphological Appearance of Iron(III) Fumarate: Impact on Material Characteristics and Biocompatibility. Chemistry of Materials. 2020 Mar 24;32(6):2253-2263. doi: 10.1021/acs.chemmater.9b03662

Kuhn J, Lin Y, Krhac LA, Al DN, Peng L, Höhn M et al. Delivery of Cas9/sgRNA Ribonucleoprotein Complexes via Hydroxystearyl Oligoamino Amides. Bioconjugate Chemistry. 2020 Mar 18;31(3):729-742. doi: 10.1021/acs.bioconjchem.9b00853

Steinborn B, Lächelt U. Metal-organic Nanopharmaceuticals. Pharmaceutical nanotechnology. 2020 Jan;8(3):163-190. doi: 10.2174/2211738508666200421113215

Steinborn B, Hirschle P, Höhn M, Bauer T, Barz M, Wuttke S et al. Core-Shell Functionalized Zirconium-Pemetrexed Coordination Nanoparticles as Carriers with a High Drug Content. Advanced Therapeutics. 2019 Nov 1;2(11):1900120. doi: 10.1002/adtp.201900120

Kuhn J, Klein PM, Al Danaf N, Nordin JZ, Reinhard S, Loy DM et al. Supramolecular Assembly of Aminoethylene-Lipopeptide PMO Conjugates into RNA Splice-Switching Nanomicelles. Advanced Functional Materials. 2019 Nov 1;29(48):1906432. doi: 10.1002/adfm.201906432

Zimpel A, Al DN, Steinborn B, Kuhn J, Höhn M, Bauer T et al. Coordinative Binding of Polymers to Metal-Organic Framework Nanoparticles for Control of Interactions at the Biointerface. ACS Nano. 2019 Mar;13(4):3884-3895. doi: 10.1021/acsnano.8b06287

Freund R, Lächelt U, Gruber T, Rühle B, Wuttke S. Multifunctional Efficiency: Extending the Concept of Atom Economy to Functional Nanomaterials. ACS Nano. 2018 Mar 27;12(3):2094-2105. doi: 10.1021/acsnano.8b00932

Hall A, Lächelt U, Bartek J, Wagner E, Moghimi SM. Polyplex Evolution: Understanding Biology, Optimizing Performance. Molecular therapy : the journal of the American Society of Gene Therapy. 2017 Jul 5;25(7):1476-1490. doi: 10.1016/j.ymthe.2017.01.024

Röder R, Preiß T, Hirschle P, Steinborn B, Zimpel A, Höhn M et al. Multifunctional Nanoparticles by Coordinative Self-Assembly of His-Tagged Units with Metal-Organic Frameworks. Journal of the American Chemical Society. 2017 Feb;139(6):2359-2368. doi: 10.1021/jacs.6b11934

21 - 40 out of 41

Ionizable Xenopeptides as a CRISPR Delivery Method

Lächelt, U. (Speaker)

11 Jun 2025

Activity: Talks and presentationsTalk or oral contributionScience to Science


Synthetic delivery systems for CRISPR/Cas genome editing

Lächelt, U. (Invited speaker)

20 Feb 2025

Activity: Talks and presentationsTalk or oral contributionScience to Science


Therapeutische Nukleinsäuren und Genom-Editierung: Aktuelle Konzepte und Entwicklungen

Lächelt, U. (Invited speaker)

24 Oct 2024

Activity: Talks and presentationsTalk or oral contributionScience to Public


Non-viral delivery of nucleic acids

Lächelt, U. (Speaker)

17 Sept 2024

Activity: Talks and presentationsTalk or oral contributionScience to Science


Xenopeptides for the delivery of CRISPR/Cas9 ribonucleoproteins

Lächelt, U. (Invited speaker)

6 Mar 2024

Activity: Talks and presentationsTalk or oral contributionScience to Science


Metal-Organic Coordination Nanoparticles for Delivery of Therapeutics

Lächelt, U. (Invited speaker)

29 Feb 2024

Activity: Talks and presentationsTalk or oral contributionScience to Science


Therapeutische Genom-Editierung - aktuelle Konzepte und Entwicklungen

Lächelt, U. (Invited speaker)

7 Feb 2024

Activity: Talks and presentationsTalk or oral contributionScience to Public


Chemical Evolution of Amphiphilic Xenopeptides for Cas9 Ribonucleoprotein Delivery

Lächelt, U. (Invited speaker)

10 Oct 2023

Activity: Talks and presentationsTalk or oral contributionScience to Science


(Metal-)Organic Nanopharmaceuticals for the Transport of Biomolecules across Cellular Barriers

Lächelt, U. (Invited speaker)

13 Sept 2023

Activity: Talks and presentationsTalk or oral contributionScience to Science


Nanopharmaceuticals for Delivery of the CRISPR/Cas System

Lächelt, U. (Invited speaker)

13 Apr 2023

Activity: Talks and presentationsTalk or oral contributionScience to Science


Artificial lipopeptides for Cas9 ribonucleoprotein delivery

Lächelt, U. (Speaker)

20 Mar 2023

Activity: Talks and presentationsTalk or oral contributionScience to Science


(Metal-)Organic Nanopharmaceuticals for the Transport of Biomolecules across Cellular Barriers

Lächelt, U. (Invited speaker)

6 Oct 2022

Activity: Talks and presentationsTalk or oral contributionScience to Public


Folate receptor-mediated delivery of Cas9 RNP for enhanced immune checkpoint disruption in cancer cells

Lächelt, U. (Invited speaker)

27 Sept 2022

Activity: Talks and presentationsTalk or oral contributionScience to Science


(Metal-)Organic Nanopharmaceuticals for the Transport of Therapeutics across Biological Barriers

Lächelt, U. (Invited speaker)

4 Jul 2022

Activity: Talks and presentationsTalk or oral contributionScience to Science


Folate-targeted Cas9/sgRNA ribonucleoprotein formulations for receptor-specific gene disruption in cancer cells

Lächelt, U. (Invited speaker)

16 Oct 2021

Activity: Talks and presentationsTalk or oral contributionScience to Science


Nanoformulations of prime editing ribonucleoproteins

Lächelt, U. (Project Lead)

1/09/2531/08/29

Project: Research funding


POM Dynamics in Cellular Membrane Transport (POM-DICT)

Rompel, A. (Project Lead), Gumerova, N. (Co-Lead) & Lächelt, U. (Co-Lead)

1/09/2531/08/29

Project: Research funding


Department of Pharmaceutical Sciences

Josef-Holaubek-Platz 2 (UZA II)
1090 Wien
Room: 2F310

T: +43-1-4277-55404

ulrich.laechelt@univie.ac.at