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Univ.-Prof. Manuela Schmidt, Ph.D.
T: +43-1-4277-55360
1 - 20 out of 36
Haroutounian S, Segelcke D, Sondermann JR, Pradier B, Vollert J, Xian F et al. Proteome-assisted multi-feature discriminant modelling of chronic post-surgical pain in female patients: A proof-of-concept study. Pharmacological Research. 2026 May;227:108175. doi: 10.1016/j.phrs.2026.108175
Sondermann JR, Barry AM, Xian F, Haberl T, Gomez-Varela D, Benseler F et al. Proximity Labelling Reveals the Compartmental Proteome of Murine Sensory Neurons. European Journal of Pain. 2026 May;30(5):e70277. doi: 10.1002/ejp.70277
Grundtner S, Xian F, Malzl D, Radits T, Barry AM, Sondermann JR et al. Temporal and demographic patterns of peripheral nerve proteomes in preclinical neuropathic pain. Biomedicine & Pharmacotherapy. 2025 Dec 4;193:118855. Epub 2025 Dec 4. doi: 10.1016/j.biopha.2025.118855
Haiss P, Liu R, Xian F, Varela DG, Schmidt M, Dirsch VM et al. Evodiamine induces centrosome amplification with subsequent G2/M cell cycle arrest in primary vascular smooth muscle cells. Biochemical Pharmacology. 2025 Dec;242(Pt 2):117320. doi: 10.1016/j.bcp.2025.117320
Barry AM, Sondermann JR, Lesnak JB, Xian F, Franco-Enzástiga Ú, O’Brien JA et al. Multi-omic integration with human dorsal root ganglia proteomics highlights TNFα signalling as a relevant sexually dimorphic pathway. Pain. 2025 Oct;166(10):2386-2402. doi: 10.1097/j.pain.0000000000003656
Xian F, Brenek M, Krisp C, Urbauer E, Kumar RKR, Aguanno D et al. Ultra-sensitive metaproteomics redefines the dark metaproteome, uncovering host-microbiome interactions and drug targets in intestinal diseases. Nature Communications. 2025 Jul 18;16:6644. doi: 10.1038/s41467-025-61977-7
Sondermann JR, Barry A, Xian F, Haberl T, Gomez Varela D, Benseler F et al. Proximity labelling reveals the compartmental proteome of murine sensory neurons. bioRxiv. 2025 Jun, p. 1-53. doi: 10.1101/2025.06.13.659475
Lohrberg M, Mortensen LS, Thomas C, Fries F, van der Meer F, Götz A et al. Astroglial modulation of synaptic function in the non-demyelinated cerebellar cortex is dependent on MyD88 signaling in a model of toxic demyelination. Journal of Neuroinflammation. 2025 Feb 23;22(1):47. doi: 10.1186/s12974-025-03368-9
Segelcke D, Sondermann JR, Kappert C, Padier B, Görlich D, Fobker M et al. Blood proteomics and multimodal risk profiling of human volunteers after incision injury: A translational study for advancing personalized pain management after surgery. Pharmacological Research. 2025 Feb;212:107580.
Xian F, Brenek M, Krisp C, Aguanno D, Urbauer E, Srikumar T et al. Ultra-sensitivity metaproteomics redefines the gut “dark metaproteome”, uncovering host-microbiome interactions and drug targets in intestinal inflammatory diseases. bioRxiv. 2025 Jan 10. doi: 10.1101/2024.04.22.590295
Grundtner S, Sondermann JR, Xian F, Malzl D, Segelcke D, Pogatzki-Zahn EM et al. Deep proteomics and network pharmacology reveal sex- and age-shared neuropathic pain signatures in mouse dorsal root ganglia. Pharmacological Research. 2025 Jan;211:107552. Epub 2024 Dec 16. doi: 10.1016/j.phrs.2024.107552
Schmidt M. Systematic review and quantitative trend analysis of scientific quality in preclinical studies using rodent models of post-surgical pain. Neuroscience and Biobehavioral Reviews . 2025. doi: 10.1016/j.neubiorev.2025.106422
Barry A, Price T, Schmidt M. Bulk Proteomics (DIA-MS) of Human Dorsal Root Ganglion v1 2024. doi: 10.17504/protocols.io.j8nlk8j56l5r/v1
Urbauer E, Aguanno D, Mindermann N, Omer H, Metwaly A, Krammel T et al. Mitochondrial perturbation in the intestine causes microbiota-dependent injury and gene signatures discriminative of inflammatory disease. Cell Host & Microbe. 2024 Aug 14;32(8):1347-1364.e10. doi: 10.1016/j.chom.2024.06.013
Barry A, Schmidt M, Price T. Bulk proteomics of naive human dorsal root ganglion 2024. doi: 10.26275/z7uy-kuif
Barry A, Sondermann JR, Lesnak J, Xian F, Franco-Enzástiga Ú, O’Brien J et al. Multi-omic integration with human DRG proteomics highlights TNFα signalling as a relevant sexually dimorphic pathway. bioRxiv. 2024. doi: 10.1101/2024.12.06.626968
Gómez-Varela D, Xian F, Grundtner S, Sondermann JR, Carta G, Schmidt M. Increasing taxonomic and functional characterization of host-microbiome interactions by DIA-PASEF metaproteomics. Frontiers in Microbiology. 2023 Oct;14:1258703. doi: 10.3389/fmicb.2023.1258703
Segelcke D, van der Burgt M, Kappert C, Schmidt Garcia D, Sondermann JR, Bigalke S et al. Phenotype- and species-specific skin proteomic signatures for incision-induced pain in humans and mice. British Journal of Anaesthesia (BJA). 2023 Mar;130(3):331-342. Epub 2023 Jan 5. doi: 10.1016/j.bja.2022.10.040
Xian F, Sondermann JR, Gomez Varela D, Schmidt M. Deep proteome profiling reveals signatures of age and sex differences in paw skin and sciatic nerve of naïve mice. eLife. 2022 Nov 30;11:e81431. doi: 10.7554/eLife.81431
Schmidt M, Sondermann JR, Gomez-Varela D, Çubuk C, Millet Q, Lewis MJ et al. Transcriptomic and proteomic profiling of NaV1.8-expressing mouse nociceptors. Frontiers in molecular neuroscience. 2022 Oct 11;15:1002842. doi: 10.3389/fnmol.2022.1002842
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Scientific Center for Neuropathic Pain AACHEN SCNAACHEN

Schmidt, M. (Keynote speaker)

2 Sept 2025

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Invited Talk: Pain Proteomics - Congress of the Spanish Pain Society

Schmidt, M. (Speaker)

30 May 2025

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Invited Talk: Congress of the Austrian Society of Pain

Schmidt, M. (Speaker)

22 May 2025

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Invited Talk: The Pain Mechanisms and Therapeutics Conference 2024: Pain Proteomics – systems biology of chronic pain

Schmidt, M. (Speaker)

17 May 2024 → 22 May 2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Nociceptor sensitization by neuro-immune interactions

Schmidt, M. (Speaker)

21 Sept 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Pain Proteomics – from the skin to the metaproteome

Schmidt, M. (Speaker)

20 Sept 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

The protein landscape of chronic pain

Schmidt, M. (Invited speaker)

1 Dec 2022

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Invited Talk: The Pain Mechanisms and Therapeutics Conference 2022

Schmidt, M. (Invited speaker)

3 Jun 2022

Activity: Talks and presentations › Talk or oral contribution › Science to Science

From TRP channels to systems biology of chronic pain

Schmidt, M. (Invited speaker)

12 Dec 2021

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Systems Biology to decipher Chronic Pain

Schmidt, M. (Invited speaker)

25 Nov 2021

Activity: Talks and presentations › Talk or oral contribution › Science to Science

TRP channel meeting Leuven 2021

Schmidt, M. (Invited speaker)

17 Sept 2021

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Inflammation, Proteomics and Chronic Pain

Schmidt, M. (Invited speaker)

10 Sept 2021

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Chronic Pain, Proteomics and Mitochondrial Dysfunction

Schmidt, M. (Invited speaker)

11 Jun 2021

Activity: Talks and presentations › Talk or oral contribution › Science to Science

PainSTRIKE: Insights into human DRG via multiomics

Schmidt, M. (Project Lead)

1/06/26 → 31/05/29

Project: Research funding

Anti-Infectives Drug Discovery

Rollinger, J. M. (Project Lead), Dailey, L. A. (Co-Lead), Orts, J. (Co-Lead), Böttcher, T. (Co-Lead), Schmidt, M. (Co-Lead), Rademacher, C. J. H. (Co-Lead), Schützenmeister, N. (Co-Lead), Zotchev, S. (Co-Lead), Kirchmair, J. (Co-Lead) & Ortmayr, K. (Co-Lead)

1/07/25 → 31/01/30

Project: Research funding

ProPEL: A Protein-based Pain Exploration Lens

Schmidt, M. (Project Lead)

1/04/25 → 30/11/27

Project: Research funding

The role of Tmem160 at the onset of pain after nerve injury

Schmidt, M. (Project Lead)

11/10/22 → 10/10/25

Project: Research funding

Pediatric chronic pain - proteome-based systems biology

Schmidt, M. (Project Lead)

15/03/22 → 14/09/25

Project: Research funding

Department of Pharmaceutical Sciences

Deputy Head
Ersthelferin

Josef-Holaubek-Platz 2 (UZA II)
1090 Wien
Room: 2D349

T: +43-1-4277-55360

manuela_schmidt@univie.ac.at