Assoz. Prof. Mag. Dr. Anna Weinzinger, Privatdoz.
T: +43-1-4277-55311
41 - 60 out of 74

Thurner P, Stary-Weinzinger A, Gafar H, Gawali VS, Kudlacek O, Zezula J et al. Mechanism of hERG channel block by the psychoactive indole alkaloid ibogaine. Journal of Pharmacology and Experimental Therapeutics. 2014 Feb;348(2):346-358. doi: 10.1124/jpet.113.209643

Saxena P, Linder T, Stary-Weinzinger A, IJzerman AP, Timin E, Ecker GF et al. Insights into Molecular Basis of hERG Inhibition by Studying a Library of Dofetilide Derivatives. Biophysical Journal. 2014 Jan 28;106(2):138a. doi: 10.1016/j.bpj.2013.11.806

Ke S, Timin E, Weinzinger A. Different inward and outward conduction mechanisms in NaVMs suggested by molecular dynamics simulations. PLoS Computational Biology. 2014;10(7):e1003746. doi: 10.1371/journal.pcbi.1003746

Lukacs P, Gawali V, Cervenka R, Ke S, Rubi L, Zarrabi T et al. Exploring the structure of the voltage-gated Na+ channel by an engineered drug access pathway to the receptor site for local anesthetics. Journal of Biological Chemistry. 2014;289(31):21770-21781. doi: 10.1074/jbc.M113.541763

Saxena P, Linder T, Weinzinger A, Timin E, Ecker GF, Hering S. Refined Molecular Model for Dofetilide-Herg Channel interaction. Indian Journal of Pharmacology. 2013 Dec;45:S32-S32.

van der Heyden MAG, Stary-Weinzinger A, Sanchez-Chapula JA. Inhibition of cardiac inward rectifier currents by cationic amphiphilic drugs. Current molecular medicine. 2013 Sept;13(8):1284-98.

Takanari H, Nalos L, Stary-Weinzinger A, de Git KCG, Varkevisser R, Linder T et al. Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue. Cardiovascular Research. 2013 Jul 1;99(1):203-214. doi: 10.1093/cvr/cvt103

Varkevisser R, Houtman MJC, Linder T, de Git KCG, Beekman HDM, Tidwell RR et al. Structure-activity relationships of pentamidine-affected ion channel trafficking and dofetilide mediated rescue. British Journal of Pharmacology. 2013 Jul;169(6):1322-1334. doi: 10.1111/bph.12208

Garg V, Stary-Weinzinger A, Sanguinetti MC. ICA-105574 interacts with a common binding site to elicit opposite effects on inactivation gating of EAG and ERG potassium channels. Molecular Pharmacology. 2013 Apr;83(4):805-813. doi: 10.1124/mol.112.084384

Saxena P, Erker T, Bauer F, Weinzinger A, Linder T, Hering S et al. Drug Trapping in hERG Channels does not Require Closure of the Activation Gate. Biophysical Journal. 2013 Jan 29;104(2):266A-266A.

Linder T, de Groot BL, Stary-Weinzinger A. Probing the energy landscape of activation gating of the bacterial potassium channel KcsA. PLoS Computational Biology. 2013;9(5):e1003058. doi: 10.1371/journal.pcbi.1003058

Beyl S, Depil K, Hohaus A, Weinzinger A, Linder T, Timin E et al. Neutralisation of a single voltage sensor affects gating determinants in all four pore-forming S6 segments of Ca(V)1.2: a cooperative gating model. Pflügers Archiv: European Journal of Physiology. 2012 Oct;464(4):391-401. doi: 10.1007/s00424-012-1144-5

Ke S, Zangerl EM, Weinzinger A. Distinct interactions of Na(+) and Ca(2+) ions with the selectivity filter of the bacterial sodium channel Na(V)Ab. Biochemical and Biophysical Research Communications. 2012;430(4):1272-1276. doi: 10.1016/j.bbrc.2012.12.055

Jansen SA, Kleerekooper I, Hofman ZLM, Kappen IFPM, Weinzinger A, van der Heyden MAG. Grayanotoxin Poisoning: 'Mad Honey Disease' and Beyond. Cardiovascular Toxicology. 2012;12(3):208-215. doi: 10.1007/s12012-012-9162-2

Phillips S, Brammer AE, Rodriguez L, Lim HH, Weinzinger A, Matulef K. Surprises from an Unusual CLC Homolog. Biophysical Journal. 2012;103(9):44-46. doi: 10.1016/j.bpj.2012.08.063

Boukharta L, Keranen H, Weinzinger A, Wallin G, De Groot B, Aqvist J. Computer simulations of structure-activity relationships for HERG channel blockers. Biochemistry. 2011;50(27):6146-6156. doi: 10.1021/bi200173n


Garg V, Weinzinger A, Sachse F, Sanguinetti MC. Molecular Determinants for Activation of Human Ether-a-go-go-related Gene 1 Potassium Channels by 3-Nitro-N-(4-phenoxyphenyl) Benzamide. Molecular Pharmacology. 2011;80(4):630-637. doi: 10.1124/mol.111.073809


41 - 60 out of 74

Research Update for the GNB1 Patient Community

Weinzinger, A. (Speaker)

29 Jun 2026

Activity: Talks and presentations › Talk or oral contribution › Science to Public


When regulation fails: Allosteric coupling in GIRK channels from Keppen–Lubinsky to GNB1 encephalopathy

Weinzinger, A. (Speaker)

15 Apr 2026

Activity: Talks and presentations › Talk or oral contribution › Science to Science


Allosteric control of GIRK channels: insights from channelopathies and drug modulation

Weinzinger, A. (Speaker)

Mar 2026

Activity: Talks and presentations › Talk or oral contribution › Science to Science


Ion Channels in Health and Disease: From Mechanistic Understanding to Therapeutic Solutions

Weinzinger, A. (Speaker)

16 Sept 2025

Activity: Talks and presentations › Talk or oral contribution › Science to Science


GNB1: Mutations, Protein Interactions, and Drug Repurposing

Weinzinger, A. (Speaker)

24 Jun 2025

Activity: Talks and presentations › Talk or oral contribution › Science to Public


GIRK2 DRUG REPURPOSING SCREEN IDENTIFIES TREATMENT OPTIONS FOR PATIENTS SUFFERING FROM EXTREMELY RARE DISEASES

Netzer, M. (Speaker), Hering, S. (Contributor), Dascal, N. (Contributor) & Weinzinger, A. (Contributor)

16 Feb 2025

Activity: Talks and presentations › Talk or oral contribution › Science to Science


Allosteric mechanisms of inward rectifier K+ channel gating probed by disease mutants and ethosuximide

Weinzinger, A. (Speaker)

12 Sept 2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science


Allosteric regulation of GIRK K+ channels

Weinzinger, A. (Speaker)

9 Jul 2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science


Allosteric mechanisms of inward rectifier K+ channel gating

Weinzinger, A. (Speaker)

23 Jun 2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science


Challenges in drug repurposing for rare diseases – the GNB1/KCNJ6 example

Weinzinger, A. (Speaker)

12 Sept 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science


Probing Inward Rectifier K+ Channel Gating and Conductance Guided by Disease Mutations

Weinzinger, A. (Speaker)

21 Jun 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science


Computational investigation of a rare disease

Friesacher, T. (Speaker) & Weinzinger, A. (Contributor)

Sept 2022 → …

Activity: Talks and presentations › Talk or oral contribution › Science to Science


Visualizing individual protonation events in Kir2 channels

Jirout, M. (Speaker), Zangerl-Plessl, E. M. (Contributor) & Weinzinger, A. (Contributor)

Sept 2022 → …

Activity: Talks and presentations › Talk or oral contribution › Science to Science


Computational investigations of ion channels

Weinzinger, A. (Speaker)

15 Sept 2019 → 20 Sept 2019

Activity: Talks and presentations › Talk or oral contribution › Science to Science


FASEB: The Ion Channel Regulation Conference: Molecules to Disease

Weinzinger, A. (Speaker)

7 Jul 2019 → 12 Jul 2019

Activity: Talks and presentations › Talk or oral contribution › Science to Science


Structure-dynamics-function relationships of inward rectifier K+ channels probed by in silico methods

Weinzinger, A. (Speaker)

27 Mar 2018

Activity: Talks and presentations › Talk or oral contribution › Science to Science


Computational investigations of cation channels

Weinzinger, A. (Speaker)

19 May 2017

Activity: Talks and presentations › Talk or oral contribution › Science to Science


In silico modelling and drug interactions in Kir6.1

Weinzinger, A. (Speaker)

4 Oct 2016

Activity: Talks and presentations › Talk or oral contribution › Other


Molecular modeling of Cantu Syndrome Channels

Weinzinger, A. (Speaker)

10 Sept 2015

Activity: Talks and presentations › Talk or oral contribution › Other


Computational investigations of hERG K+ channels

Weinzinger, A. (Speaker)

10 Aug 2015

Activity: Talks and presentations › Talk or oral contribution › Other


MD SIMULATIONS OF KIRBAC1.1 MUTANTS REVEAL GATING CHANGES AT THE BUNDLE CROSSING REGION

Weinzinger, A. (Speaker)

4 Feb 2013

Activity: Talks and presentations › Talk or oral contribution › Other


Investigating the structural basis of hERG channel block guided by molecular dynamics simulations

Weinzinger, A. (Speaker)

25 Sept 2012

Activity: Talks and presentations › Talk or oral contribution › Other


In silico modelling of Kir2.x channels

Weinzinger, A. (Speaker)

2011 → …

Activity: Talks and presentations › Talk or oral contribution › Science to Science


IK1 block by small molecules

Weinzinger, A. (Speaker)

2010 → …

Activity: Talks and presentations › Talk or oral contribution › Other


In silico prediction of the cardiotoxicity of drug candidates

Weinzinger, A. (Speaker)

2008 → …

Activity: Talks and presentations › Talk or oral contribution › Science to Science


Modelling the hERG K+ channel

Weinzinger, A. (Speaker)

2008 → …

Activity: Talks and presentations › Talk or oral contribution › Science to Science


Towards a consensus model of the hERG K+ channel

Weinzinger, A. (Speaker)

2008 → …

Activity: Talks and presentations › Talk or oral contribution › Other


Computer modeling strategies to investigate the molecular basis of odor discrimination

Weinzinger, A. (Speaker)

2006 → …

Activity: Talks and presentations › Talk or oral contribution › Science to Science


Decoding GNB1E: Advanced Drug Repurposing for Personalized Treatment (GNB1E)

Weinzinger, A. (Project Lead), Nicole, A. (Co-Lead) & Dascal, N. (Co-Lead)

1/09/26 → 31/08/30

Project: Research funding


Novel approaches to investigate the regulation of G-protein coupled inward rectifier K+ channels by Gβγ

Weinzinger, A. (Project Lead) & Friesacher, T. (Co-Lead)

1/08/21 → 31/07/24

Project: Research funding


PROSTAGLANDINES - POTENTIAL THERAPEUTICS FOR DEND SYNDROME?

Weinzinger, A. (Project Lead)

1/12/20 → 30/07/23

Project: Research funding


Sulfonylharnstoffe

Weinzinger, A. (Project Lead)

1/03/15 → 28/02/19

Project: Research funding


hERG K+ Channel activators

Weinzinger, A. (Project Lead)

4/11/14 → 4/11/15

Project: Research funding


hEAG1 channel blockers

Weinzinger, A. (Project Lead)

15/03/14 → 14/03/15

Project: Research funding


Molecular Drug Targets

Hering, S. (Project Lead), Ecker, G. (Co-Lead), Maulide, N. (Co-Lead), Weinzinger, A. (Co-Lead) & Gonzalez Herrero, L. (Co-Lead)

1/12/10 → 31/12/22

Project: Research funding


hERG potassium channel

Weinzinger, A. (Project Lead)

27/10/10 → 31/12/11

Project: Research funding


Department of Pharmaceutical Sciences

Josef-Holaubek-Platz 2 (UZA II)
1090 Wien
Room: 2D178

T: +43-1-4277-55311

anna.stary@univie.ac.at