Ass.-Prof. Mag. Dr. Sophia Khom-Steinkellner
T: +43-1-4277-55035
Winter term 2025
Summer term 2025
321015 VO Pathophysiologie - B8
322059 VU Psychoaktive Substanzen - M14 - chemische und pharmakologische Betrachtungen
322085 VU Fortschritte in der Behandlung der kognitiven Alterung - M14 - relevante Aspekte für angehende Pharmazeut*innen
Winter term 2024
251037 VO Pharmakologie
Lackner J, Alberti C, Bock T, Neßmerak K, Urban E, Khom S et al. Total Synthesis of (15R)- and (15S)-Prostaglandin A2. Chemistry - A European Journal. 2024 Sept 5;30(50):e202401921. Epub 2024 Jun 14. doi: 10.1002/chem.202401921
Vlkolinsky R, Khom S, Vozella V, Bajo M, Roberto M. Withdrawal from chronic alcohol impairs the serotonin-mediated modulation of GABAergic transmission in the infralimbic cortex in male rats. Neurobiology of disease. 2024 Sept;199:106590. doi: 10.1016/j.nbd.2024.106590
Borgonetti V, Cruz B, Vozella V, Khom S, Steinman MQ, Bullard R et al. IL-18 Signaling in the Rat Central Amygdala Is Disrupted in a Comorbid Model of Post-Traumatic Stress and Alcohol Use Disorder. Cells. 2023 Jul 27;12(15):1943. doi: 10.3390/cells12151943
Khom S, Borgonetti V, Vozella V, Kirson D, Rodriguez L, Gandhi P et al. Glucocorticoid receptors regulate central amygdala GABAergic synapses in Marchigian-Sardinian alcohol-preferring rats. Neurobiology of Stress. 2023 Jul;25:100547. doi: 10.1016/j.ynstr.2023.100547
Chuong V, Farokhnia M, Khom S, Pince CL, Elvig SK, Vlkolinsky R et al. The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission. Journal of Clinical Investigation Insight. 2023 Jun 22;8(12):e170671. Epub 2023. doi: 10.1172/jci.insight.170671
Rodriguez L, Kirson D, Wolfe SA, Patel RR, Varodayan FP, Snyder AE et al. Alcohol Dependence Induces CRF Sensitivity in Female Central Amygdala GABA Synapses. International Journal of Molecular Sciences. 2022 Jul 16;23(14):7842. doi: 10.3390/ijms23147842
Varodayan FP, Patel RR, Matzeu A, Wolfe SA, Curley DE, Khom S et al. The Amygdala Noradrenergic System Is Compromised With Alcohol Use Disorder. Biological Psychiatry. 2022 Jun 15;91(12):1008-1018. doi: 10.1016/j.biopsych.2022.02.006
Wolfe SA, Khom S, Breit KR, Xu JC, Nguyen JD, Creehan KM et al. PRENATAL THC AND ALCOHOL EXPOSURE INDUCES LASTING NEUROADAPTATIONS IN THE CENTRAL NUCLEUS OF THE AMYGDALA. Alcoholism: Clinical and Experimental Research. 2022 Jun;46:196A-196A.
Khom S, Rodriguez L, Gandhi P, Kirson D, Bajo M, Oleata CS et al. Alcohol dependence and withdrawal increase sensitivity of central amygdalar GABAergic synapses to the glucocorticoid receptor antagonist mifepristone in male rats. Neurobiology of disease. 2022 Mar 1;164:105610. doi: 10.1016/j.nbd.2022.105610
Khom S, Nguyen JD, Vandewater SA, Grant Y, Roberto M, Taffe MA. Self-Administration of Entactogen Psychostimulants Dysregulates Gamma-Aminobutyric Acid (GABA) and Kappa Opioid Receptor Signaling in the Central Nucleus of the Amygdala of Female Wistar Rats. Frontiers in Behavioral Neuroscience . 2021 Dec 16;15:780500. doi: 10.3389/fnbeh.2021.780500
Kirson D, Khom S, Rodriguez L, Wolfe SA, Varodayan FP, Gandhi PJ et al. Sex Differences in Acute Alcohol Sensitivity of Naive and Alcohol Dependent Central Amygdala GABA Synapses. Alcohol & Alcoholism. 2021 Sept;56(5):581–588. agab034. Epub 2021 Apr 29. doi: 10.1093/alcalc/agab034
Steinman MQ, Kirson D, Wolfe SA, Khom S, D'Ambrosio SR, Spierling Bagsic SR et al. Importance of sex and trauma context on circulating cytokines and amygdalar GABAergic signaling in a comorbid model of posttraumatic stress and alcohol use disorders. Molecular Psychiatry. 2021 Jul;26(7):3093-3107. Epub 2020 Oct 21. doi: 10.1038/s41380-020-00920-2
Kirson D, Khom S, Rodriguez L, Wolfe SA, Varodayan FP, Gandhi PJ et al. CENTRAL AMYGDALA GABA SYNAPSES OF ALCOHOL NAIVE AND DEPENDENT FEMALES ARE LESS SENSITIVE TO ACUTE ALCOHOL COMPARED TO MALE RATS. Alcoholism: Clinical and Experimental Research. 2021 Jun;45(S1):148A-148A. 302. doi: 10.1111/acer.14628
Khom S, Kirson D, Oleata C, Roberto M. MIFEPRISTONE DECREASES GABA TRANSMISSION IN THE CENTRAL NUCLEUS OF THE AMYGDALA - ROLE OF SEX AND ALCOHOL HISTORY. Alcoholism: Clinical and Experimental Research. 2021 Jun;45(S1):56A-56A. 190. doi: 10.1111/acer.14617
Wolfe SA, Khom S, Breit KR, Nguyen JD, Creehan KM, Thomas JD et al. PRENATAL THC AND ALCOHOL EXPOSURE INDUCES LASTING NEUROADAPTATIONS IN THE CENTRAL NUCLEUS OF THE AMYGDALA. Alcoholism: Clinical and Experimental Research. 2021 Jun;45(S1):158A-159A. 351. doi: 10.1111/acer.14628
Roberto M, Kirson D, Khom S. The role of the central amygdala in alcohol dependence. In The role of the central amygdala in alcohol dependence. 2 ed. Vol. 11. 2021. p. 1-23. (Cold Spring Harbor perspectives in medicine). doi: 10.1101/cshperspect.a039339
Warden AS, Wolfe SA, Khom S, Varodayan FP, Patel RR, Steinman MQ et al. Microglia Control Escalation of Drinking in Alcohol-Dependent Mice: Genomic and Synaptic Drivers. Biological Psychiatry. 2020 Dec 15;88(12):910-921. doi: 10.1016/j.biopsych.2020.05.011
Demoret RM, Baker MA, Ohtawa M, Chen S, Lam CC, Khom S et al. Synthetic, Mechanistic, and Biological Interrogation of Ginkgo biloba Chemical Space En Route to (-)-Bilobalide. Journal of the American Chemical Society. 2020 Oct 28;142(43):18599-18618. doi: 10.1021/jacs.0c08231
Khom S, Wolfe SA, Patel RR, Kirson D, Hedges DM, Varodayan FP et al. Alcohol Dependence and Withdrawal Impair Serotonergic Regulation of GABA Transmission in the Rat Central Nucleus of the Amygdala. Journal of Neuroscience. 2020 Sept 2;40(36):6842-6853. doi: 10.1523/JNEUROSCI.0733-20.2020
Suarez J, Khom S, Alen F, Natividad LA, Varodayan FP, Patel RR et al. Cessation of fluoxetine treatment increases alcohol seeking during relapse and dysregulates endocannabinoid and glutamatergic signaling in the central amygdala. Addiction Biology. 2020 Sept;25(5):e12813. doi: 10.1111/adb.12813
Glucocorticoid regulation of GABA signaling in the central amygdala in alcohol use disorder
Khom-Steinkellner, S. (Speaker)
26 Jun 2024
Activity: Talks and presentations › Talk or oral contribution › Science to Science
Acute effects of the glucocorticoid receptor antagonist mifepristone on GABA signaling in the central nucleus of the amygdala: Impact of alcohol history, strain and sex.
Khom-Steinkellner, S. (Speaker)
26 Sept 2022
Activity: Talks and presentations › Talk or oral contribution › Science to Science
Mifepristone decreases GABA transmission in the central nucleus of the amygdala –role of alcohol history and sex
Khom-Steinkellner, S. (Speaker)
22 Jun 2021
Activity: Talks and presentations › Talk or oral contribution › Science to Science
Aberrant central amygdala Substance P/Neurokinin 1 receptor signaling in alcohol dependence
Khom-Steinkellner, S. (Speaker)
21 Sept 2019 → 24 Sept 2019
Activity: Talks and presentations › Talk or oral contribution › Science to Science
5 years of Screeing Tool : n automated medium throughput fast oocyte perfusion system
Khom, S. (Contributor)
20 Feb 2010
Activity: Talks and presentations › Talk or oral contribution › Other
GABBAA-Receptors: Potential target for various natural products.
Khom, S. (Speaker)
10 Dec 2007
Activity: Talks and presentations › Talk or oral contribution › Other
Benzodiazepines eliminate gamma subunit mediated suppression of GABA sensitivity of GABAA receptors
Khom, S. (Contributor)
3 Nov 2007
Activity: Talks and presentations › Talk or oral contribution › Other
HPLC-based Activity Profiling of Plant and Fungal Extracts for GABAA Receptor Ligands using a Functional Assay with Xenopus Oocytes
Khom, S. (Speaker)
2 Sept 2007
Activity: Talks and presentations › Talk or oral contribution › Other
Mutations in the GABA_A gamma2 subunit.
Khom, S. (Speaker)
10 Jan 2007
Activity: Talks and presentations › Talk or oral contribution › Other
A NOVEL METHOD FOR MEDIUM-THROUGHPUT SCREENING OF HERBAL SEDATIVES AND BENZODIAZEPINE-LIKE LIGANDS ON GABAA-RECEPTORS EXPRESSED IN XENOPUS OOCYTES
Khom, S. (Speaker)
20 Apr 2006
Activity: Talks and presentations › Talk or oral contribution › Other
Pharmacological properties of GABAA- receptors containing gamma1 subunits
Khom, S. (Speaker)
24 Nov 2005
Activity: Talks and presentations › Talk or oral contribution › Other
Role of SOX6 in parkinsonism and neurodevelopmental disease
Steinkellner, T. (Co-Lead) & Khom-Steinkellner, S. (Project Lead)
Project: Research funding
Becoming bilingual through transmitter co-release
Khom-Steinkellner, S. (Project Lead)
3/10/22 → 2/10/25
Project: Research funding
Department of Pharmaceutical Sciences
Josef-Holaubek-Platz 2 (UZA II)
1090 Wien
Room: 2E360
T: +43-1-4277-55035