Einzelansicht Khom

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Ass.-Prof. Mag. Dr. Sophia Khom-Steinkellner

T: +43-1-4277-55035

sophia.khom-steinkellner@univie.ac.at

Winter term 2024

251037 VO Pharmakologie

321023 VO Trenn- und Analysemethoden org. Arzneistoffe inkl. bioanalyt. Methoden - B12

322027 VU Ausgewählte Kapitel aus der pharmakologischen Forschung - M13

322058 VU Substanz-Missbrauch und missbräuchlich verwendete Substanzen - M14

Summer term 2024

321015 VO Pathophysiologie - B8

321023 VO Trenn- und Analysemethoden org. Arzneistoffe inkl. bioanalyt. Methoden - B12

Winter term 2023

251037 VO Pharmakologie

321023 VO Trenn- und Analysemethoden org. Arzneistoffe inkl. bioanalyt. Methoden - B12

321037 VU Pharmazeutische Wissenschaften - B20

322023 VU Ausgewählte Kapitel aus der pharmakologischen Forschung - M13

Lackner J, Alberti C, Bock T, Neßmerak K, Urban E , Khom S et al. Total Synthesis of (15R)- and (15S)-Prostaglandin A₂. Chemistry - A European Journal. 2024 Sep 5;30(50):e202401921. Epub 2024 Jun 14. doi: 10.1002/chem.202401921

Vlkolinsky R, Khom S, Vozella V, Bajo M, Roberto M. Withdrawal from chronic alcohol impairs the serotonin-mediated modulation of GABAergic transmission in the infralimbic cortex in male rats. Neurobiology of disease. 2024 Sep;199:106590. doi: 10.1016/j.nbd.2024.106590

Borgonetti V, Cruz B, Vozella V, Khom S, Steinman MQ, Bullard R et al. IL-18 Signaling in the Rat Central Amygdala Is Disrupted in a Comorbid Model of Post-Traumatic Stress and Alcohol Use Disorder. Cells. 2023 Jul 27;12(15):1943. doi: 10.3390/cells12151943

Khom S, Borgonetti V, Vozella V, Kirson D, Rodriguez L, Gandhi P et al. Glucocorticoid receptors regulate central amygdala GABAergic synapses in Marchigian-Sardinian alcohol-preferring rats. Neurobiology of Stress. 2023 Jul;25:100547. doi: 10.1016/j.ynstr.2023.100547

Chuong V, Farokhnia M, Khom S, Pince CL, Elvig SK, Vlkolinsky R et al. The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission. Journal of Clinical Investigation Insight. 2023 Jun 22;8(12):e170671. Epub 2023. doi: 10.1172/jci.insight.170671

Rodriguez L, Kirson D, Wolfe SA, Patel RR, Varodayan FP, Snyder AE et al. Alcohol Dependence Induces CRF Sensitivity in Female Central Amygdala GABA Synapses. International Journal of Molecular Sciences. 2022 Jul 16;23(14):7842. doi: 10.3390/ijms23147842

Varodayan FP, Patel RR, Matzeu A, Wolfe SA, Curley DE, Khom S et al. The Amygdala Noradrenergic System Is Compromised With Alcohol Use Disorder. Biological Psychiatry. 2022 Jun 15;91(12):1008-1018. doi: 10.1016/j.biopsych.2022.02.006

Wolfe SA, Khom S, Breit KR, Xu JC, Nguyen JD, Creehan KM et al. PRENATAL THC AND ALCOHOL EXPOSURE INDUCES LASTING NEUROADAPTATIONS IN THE CENTRAL NUCLEUS OF THE AMYGDALA. Alcoholism: Clinical and Experimental Research. 2022 Jun;46:196A-196A.

Khom S, Rodriguez L, Gandhi P, Kirson D, Bajo M, Oleata CS et al. Alcohol dependence and withdrawal increase sensitivity of central amygdalar GABAergic synapses to the glucocorticoid receptor antagonist mifepristone in male rats. Neurobiology of disease. 2022 Mar 1;164:105610. doi: 10.1016/j.nbd.2022.105610

Khom S, Nguyen JD, Vandewater SA, Grant Y, Roberto M, Taffe MA. Self-Administration of Entactogen Psychostimulants Dysregulates Gamma-Aminobutyric Acid (GABA) and Kappa Opioid Receptor Signaling in the Central Nucleus of the Amygdala of Female Wistar Rats. Frontiers in Behavioral Neuroscience . 2021 Dec 16;15:780500. doi: 10.3389/fnbeh.2021.780500

Kirson D, Khom S, Rodriguez L, Wolfe SA, Varodayan FP, Gandhi PJ et al. Sex Differences in Acute Alcohol Sensitivity of Naive and Alcohol Dependent Central Amygdala GABA Synapses. Alcohol & Alcoholism. 2021 Sep;56(5):581–588. agab034. Epub 2021 Apr 29. doi: 10.1093/alcalc/agab034

Steinman MQ, Kirson D, Wolfe SA, Khom S, D'Ambrosio SR, Spierling Bagsic SR et al. Importance of sex and trauma context on circulating cytokines and amygdalar GABAergic signaling in a comorbid model of posttraumatic stress and alcohol use disorders. Molecular Psychiatry. 2021 Jul;26(7):3093-3107. Epub 2020 Oct 21. doi: 10.1038/s41380-020-00920-2

Kirson D, Khom S, Rodriguez L, Wolfe SA, Varodayan FP, Gandhi PJ et al. CENTRAL AMYGDALA GABA SYNAPSES OF ALCOHOL NAIVE AND DEPENDENT FEMALES ARE LESS SENSITIVE TO ACUTE ALCOHOL COMPARED TO MALE RATS. Alcoholism: Clinical and Experimental Research. 2021 Jun;45(S1):148A-148A. 302. doi: https://doi.org/10.1111/acer.14628

Khom S, Kirson D, Oleata C, Roberto M. MIFEPRISTONE DECREASES GABA TRANSMISSION IN THE CENTRAL NUCLEUS OF THE AMYGDALA - ROLE OF SEX AND ALCOHOL HISTORY. Alcoholism: Clinical and Experimental Research. 2021 Jun;45(S1):56A-56A. 190. doi: https://doi.org/10.1111/acer.14617

Wolfe SA, Khom S, Breit KR, Nguyen JD, Creehan KM, Thomas JD et al. PRENATAL THC AND ALCOHOL EXPOSURE INDUCES LASTING NEUROADAPTATIONS IN THE CENTRAL NUCLEUS OF THE AMYGDALA. Alcoholism: Clinical and Experimental Research. 2021 Jun;45(S1):158A-159A. 351. doi: https://doi.org/10.1111/acer.14628

Roberto M, Kirson D, Khom S. The role of the central amygdala in alcohol dependence. In The role of the central amygdala in alcohol dependence. 2 ed. Vol. 11. 2021. p. 1-23. (Cold Spring Harbor perspectives in medicine). doi: 10.1101/cshperspect.a039339

Warden AS, Wolfe SA, Khom S, Varodayan FP, Patel RR, Steinman MQ et al. Microglia Control Escalation of Drinking in Alcohol-Dependent Mice: Genomic and Synaptic Drivers. Biological Psychiatry. 2020 Dec 15;88(12):910-921. doi: 10.1016/j.biopsych.2020.05.011

Demoret RM, Baker MA, Ohtawa M, Chen S, Lam CC, Khom S et al. Synthetic, Mechanistic, and Biological Interrogation of Ginkgo biloba Chemical Space En Route to (-)-Bilobalide. Journal of the American Chemical Society. 2020 Oct 28;142(43):18599-18618. doi: 10.1021/jacs.0c08231

Khom S, Wolfe SA, Patel RR, Kirson D, Hedges DM, Varodayan FP et al. Alcohol Dependence and Withdrawal Impair Serotonergic Regulation of GABA Transmission in the Rat Central Nucleus of the Amygdala. Journal of Neuroscience. 2020 Sep 2;40(36):6842-6853. doi: 10.1523/JNEUROSCI.0733-20.2020

Suarez J, Khom S, Alen F, Natividad LA, Varodayan FP, Patel RR et al. Cessation of fluoxetine treatment increases alcohol seeking during relapse and dysregulates endocannabinoid and glutamatergic signaling in the central amygdala. Addiction Biology. 2020 Sep;25(5):e12813. doi: 10.1111/adb.12813

Acute effects of the glucocorticoid receptor antagonist mifepristone on GABA signaling in the central nucleus of the amygdala: Impact of alcohol history, strain and sex.

Sophia Khom-Steinkellner (Speaker)

26 Sep 2022

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Mifepristone decreases GABA transmission in the central nucleus of the amygdala –role of alcohol history and sex

Sophia Khom-Steinkellner (Speaker)

22 Jun 2021

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Aberrant central amygdala Substance P/Neurokinin 1 receptor signaling in alcohol dependence

Sophia Khom-Steinkellner (Speaker)

21 Sep 2019 → 24 Sep 2019

Activity: Talks and presentations › Talk or oral contribution › Science to Science