Ass.-Prof. Dr. Ulrich Lächelt
T: +43-1-4277-55404
1 - 20 out of 35
Zhu X, Shi Z, Mao Y, Lächelt U, Huang R. Cell Membrane Perforation: Patterns, Mechanisms and Functions. Small. 2024 Jun 12;20(24):2310605. Epub 2024. doi: 10.1002/smll.202310605

Germer J, Lessl AL, Pöhmerer J, Grau M, Weidinger E, Höhn M et al. Lipo-Xenopeptide Polyplexes for CRISPR/Cas9 based Gene editing at ultra-low dose. Journal of Controlled Release. 2024 Jun;370:239-255. Epub 2024 Apr 27. doi: 10.1016/j.jconrel.2024.04.037

Zhou F, Huang L, Li S, Yang W, Chen F, Cai Z et al. From structural design to delivery: mRNA therapeutics for cancer immunotherapy. Exploration. 2024 Apr;4(2):20210146. doi: 10.1002/EXP.20210146


Albuquerque LJC, de Oliveira FA, Christoffolete MA, Nascimento-Sales M, Berger S, Wagner E et al. Nucleic acid delivery to retinal cells using lipopeptides as a potential tool towards ocular gene therapies. Journal of Colloid and Interface Science. 2024 Feb;655:346-356. doi: 10.1016/j.jcis.2023.11.003

Lyu M, Yazdi M, Lin Y, Höhn M, Lächelt U, Wagner E. Receptor-Targeted Dual pH-Triggered Intracellular Protein Transfer. ACS Biomaterials Science & Engineering. 2024 Jan 8;10(1):99-114. Epub 2022 Jul 8. doi: 10.1021/acsbiomaterials.2c00476

Lessl AL, Pöhmerer J, Lin Y, Wilk U, Höhn M, Hörterer E et al. mCherry on Top: A Positive Read-Out Cellular Platform for Screening DMD Exon Skipping Xenopeptide-PMO Conjugates. Bioconjugate Chemistry. 2023 Dec 20;34(12):2263-2274. Epub 2023 Nov 22. doi: 10.1021/acs.bioconjchem.3c00408

Öztürk Ö, Lessl AL, Höhn M, Wuttke S, Nielsen PE, Wagner E et al. Peptide nucleic acid-zirconium coordination nanoparticles. Scientific Reports. 2023 Dec;13(1):14222. doi: 10.1038/s41598-023-40916-w

Liu Z, Zimpel A, Lächelt U, Pozzi M, Gonzalez MG, Chakraborty I et al. Uptake and Intracellular Fate of Fluorophore Labeled Metal–Organic-Framework (MOF) Nanoparticles: Environment & Health. Environment & Health. 2023 Oct 20;1(4):270-277. doi: 10.1021/envhealth.3c00075


Lin Y, Luo X, Burghardt T, Dorrer S, Höhn M, Wagner E et al. Chemical Evolution of Amphiphilic Xenopeptides for Potentiated Cas9 Ribonucleoprotein Delivery. Journal of the American Chemical Society. 2023 Jul 19;145(28):15171-15179. doi: 10.1021/jacs.3c01902

Shen F, Lin Y, Höhn M, Luo X, Döblinger M, Wagner E et al. Iron-Gallic Acid Peptide Nanoparticles as a Versatile Platform for Cellular Delivery with Synergistic ROS Enhancement Effect. Pharmaceutics. 2023 Jul;15(7):1789. doi: 10.3390/pharmaceutics15071789


Lin Y, Wilk U, Pöhmerer J, Hörterer E, Höhn M, Luo X et al. Folate Receptor-Mediated Delivery of Cas9 RNP for Enhanced Immune Checkpoint Disruption in Cancer Cells. Small. 2023 Jan 11;19(2):e2205318. Epub 2022 Nov 18. doi: 10.1002/smll.202205318

Mirzazadeh Dizaji N, Lin Y, Bein T, Wagner E, Wuttke S, Lächelt U et al. Biomimetic Mineralization of Iron-Fumarate Nanoparticles for Protective Encapsulation and Intracellular Delivery of Proteins. Chemistry of Materials. 2022 Oct 11;34(19):8684-8693. doi: 10.1021/acs.chemmater.2c01736


Huo T, Zhang X, Qian M, Nie H, Liang D, Lin C et al. A Space-Time Conversion Vehicle for Programmed Multi-Drugs Delivery into Pancreatic Tumor to Overcome Matrix and Reflux Barriers. Advanced science. 2022 Jul;9(20):2200608. doi: 10.1002/advs.202200608

Capelôa L, Yazdi M, Zhang H, Chen X, Nie Y, Wagner E et al. Cross-Linkable Polyion Complex Micelles from Polypept(o)ide-Based ABC-Triblock Copolymers for siRNA Delivery. Macromolecular Rapid Communications. 2022 Jun;43(12):2100698. Epub 2021 Dec 30. doi: 10.1002/marc.202100698

Andreo J, Ettlinger R, Zaremba O, Peña Q, Lächelt U, de Luis RF et al. Reticular Nanoscience: Bottom-Up Assembly Nanotechnology. Journal of the American Chemical Society. 2022 Apr 7;144(17):7531-7550. Epub 2022 Apr 7. doi: 10.1021/jacs.1c11507

Lin Y, Wagner E, Lächelt U. Non-viral delivery of the CRISPR/Cas system: DNA versus RNA versus RNP. Biomaterials Science. 2022 Jan 25;10(5):1166-1192. doi: 10.1039/d1bm01658j

1 - 20 out of 35

Therapeutische Nukleinsäuren und Genom-Editierung: Aktuelle Konzepte und Entwicklungen

Ulrich Lächelt (Speaker)

24 Oct 2024

Activity: Talks and presentationsTalk or oral contributionScience to Public


Xenopeptides for the delivery of CRISPR/Cas9 ribonucleoproteins

Ulrich Lächelt (Speaker)

6 Mar 2024

Activity: Talks and presentationsTalk or oral contributionScience to Science


Metal-Organic Coordination Nanoparticles for Delivery of Therapeutics

Ulrich Lächelt (Speaker)

29 Feb 2024

Activity: Talks and presentationsTalk or oral contributionScience to Science


Therapeutische Genom-Editierung - aktuelle Konzepte und Entwicklungen

Ulrich Lächelt (Speaker)

7 Feb 2024

Activity: Talks and presentationsTalk or oral contributionScience to Public


Chemical Evolution of Amphiphilic Xenopeptides for Cas9 Ribonucleoprotein Delivery

Ulrich Lächelt (Speaker)

10 Oct 2023

Activity: Talks and presentationsTalk or oral contributionScience to Science


(Metal-)Organic Nanopharmaceuticals for the Transport of Biomolecules across Cellular Barriers

Ulrich Lächelt (Speaker)

13 Sept 2023

Activity: Talks and presentationsTalk or oral contributionScience to Science


Nanopharmaceuticals for Delivery of the CRISPR/Cas System

Ulrich Lächelt (Speaker)

13 Apr 2023

Activity: Talks and presentationsTalk or oral contributionScience to Science


Artificial lipopeptides for Cas9 ribonucleoprotein delivery

Ulrich Lächelt (Speaker)

20 Mar 2023

Activity: Talks and presentationsTalk or oral contributionScience to Science


(Metal-)Organic Nanopharmaceuticals for the Transport of Biomolecules across Cellular Barriers

Ulrich Lächelt (Speaker)

6 Oct 2022

Activity: Talks and presentationsTalk or oral contributionScience to Public


Folate receptor-mediated delivery of Cas9 RNP for enhanced immune checkpoint disruption in cancer cells

Ulrich Lächelt (Speaker)

27 Sept 2022

Activity: Talks and presentationsTalk or oral contributionScience to Science


(Metal-)Organic Nanopharmaceuticals for the Transport of Therapeutics across Biological Barriers

Ulrich Lächelt (Speaker)

4 Jul 2022

Activity: Talks and presentationsTalk or oral contributionScience to Science


Folate-targeted Cas9/sgRNA ribonucleoprotein formulations for receptor-specific gene disruption in cancer cells

Ulrich Lächelt (Speaker)

16 Oct 2021

Activity: Talks and presentationsTalk or oral contributionScience to Science


Department of Pharmaceutical Sciences

Josef-Holaubek-Platz 2 (UZA II)
1090 Wien
Room: 2F310

T: +43-1-4277-55404

ulrich.laechelt@univie.ac.at