Einzelansicht Rademacher

Univ.-Prof. Dr. Christoph Johannes Heinrich Rademacher, B.Sc. M.Sc.

T: +43-1-4277-55578

christoph.rademacher@univie.ac.at

Summer term 2025

301813 VO MPM 3 - Lecture course: Fundamentals of enzymology, diseases and their clinical manifestation - manifestation, and technologies to correct enzymatic insufficiency

301818 VO MPM 7 - Lecture course: Clinical trial design

301843 UE Practical Course in Molecular and Cellular Immunobiology

322029 VU Ausgewählte Kapitel aus der pharmazeutisch-technologischen Forschung - M13

322575 VO Pharmazeutische Nanotechnologie - Lipid-basierte Applikationen - M7/M14

323104 VU Biophysics in Drug Discovery - MPS5

323151 VU Fragment-based Drug Design - MPS10

Winter term 2024

301817 VO MPM 7 - Lecture course: Model systems in precision medicine - in the context of signature diseases

301818 SE MPM 7 - Seminar, Journal Club and Case Studies: Model systems in precision medicine - in the context of signature diseases

301849 UE Scientific Practice in Molecular Microbiology, Ecology or Immunobiology

322029 VU Ausgewählte Kapitel aus der pharmazeutisch-technologischen Forschung - M13

322072 VO Drug Targeting - Controlled delivery to target tissues - M7/M14

322575 VO Pharmazeutische Nanotechnologie - Lipid-basierte Applikationen - M7/M14

Summer term 2024

301813 VO MPM 3 - Lecture course: Fundamentals of enzymology, diseases and their clinical manifestation - manifestation, and technologies to correct enzymatic insufficiency

301818 VO MPM 7 - Lecture course: Clinical trial design

301843 UE Practical Course in Molecular and Cellular Immunobiology

301861 UE Wahlbeispiel Molekulare Biologie II

322025 VU Ausgewählte Kapitel aus der pharmazeutisch-technologischen Forschung - M13

322575 VO Pharmazeutische Nanotechnologie - Lipid-basierte Applikationen - M7/M14

323104 VU Biophysics in Drug Discovery - MPS5

323151 VU Fragment-based Drug Design - MPS10

Rahhal N, Rentzsch M, Seiser S, Freystätter C, Elbe-Bürger A, Rademacher C. Targeted delivery of cytotoxic proteins via lipid-based nanoparticles to primary Langerhans cells. Nanoscale. 2025 Jan 7;17(7):4038-4046. doi: 10.1039/d4nr03638g

Lefèbre J , Falk T , Ning Y , Rademacher C. Secondary Sites of the C-type Lectin-Like Fold. Chemistry: A European Journal. 2024 May 28;30(30):e202400660. doi: 10.1002/chem.202400660

Leusmann S, Ménová P, Shanin E, Titz A, Rademacher C. Glycomimetics for the inhibition and modulation of lectins. Chemical Society Reviews. 2023 May 26;52(11):3663-3740. doi: 10.1039/d2cs00954d

Fuchsberger FF, Kim D, Baranova N, Vrban H, Kagelmacher M, Wawrzinek R et al. Information transfer in mammalian glycan-based communication. eLife. 2023 Feb 20;12:e69415. doi: 10.7554/eLife.69415

Stoitzner P, Romani N, Rademacher CJH, Probst HC, Mahnke K. Antigen targeting to dendritic cells: still a place in future immunotherapy? European Journal of Immunology. 2022 Dec;52(12):1909-1924. doi: 10.1002/eji.202149515

Hengxi Z, Modenutti C, Nekkanti YPK, Denis M, Bermejo IA, Lefèbre J et al. Identification of the Allosteric Binding Site for Thiazolopyrimidine on the C-Type Lectin Langerin. ACS Chemical Biology. 2022 Oct 21;17(10):2728–2733. Epub 2022 Sept 26. doi: 10.1021/acschembio.2c00626

Paris G, Heidepriem J, Tsouka A, Liu Y, Mattes DS, Pinzón Martín S et al. Automated Laser-Transfer Synthesis of High-Density Microarrays for Infectious Disease Screening. Advanced Materials. 2022 Jun 9;34(23):2200359. doi: 10.1002/adma.202200359

Hengxi Z, Daněk O, Makarov D, Rádl S, Kim D, Ledvinka J et al. Drug-like Inhibitors of DC-SIGN Based on a Quinolone Scaffold. ACS Medicinal Chemistry Letters . 2022 Jun 9;13(6):935-942. doi: 10.1021/acsmedchemlett.2c00067

Shanina E, Kuhaudomlarp S, Siebs E, Fuchsberger FFR, Denis M, da Silva Figueiredo Celestino Gomes P et al. Targeting undruggable carbohydrate recognitionsites through focused fragment library design. Communications Chemistry. 2022 May 20;5:64. doi: 10.1038/s42004-022-00679-3

Ghosh C, Priegue P, Leelayuwapan H, Fuchsberger FF, Rademacher CJH, Seeberger PH. Synthetic Glyconanoparticles Modulate Innate Immunity but Not the Complement System. ACS applied bio materials. 2022 Apr 18;5(5):2185-2192. doi: 10.1021/acsabm.2c00026

Siebs E, Shanina E, Kuhaudomlarp S, da Silva Figueiredo Celestino Gomes P, Fortin C, Seeberger PH et al. Targeting the Central Pocket of the Pseudomonas aeruginosa Lectin LecA. ChemBioChem: a european journal of chemical biology. 2022 Feb 4;23(3):e202100563. Epub 2021 Nov 17. doi: 10.1002/cbic.202100563

Shanina E, Kuhaudomlarp S, Lal K, Seeberger PH, Imberty A, Rademacher CJH. Druggable Allosteric Sites in β-Propeller Lectins. Angewandte Chemie (International Edition). 2022 Jan 3;61(1):e202109339. doi: 10.1002/anie.202109339

Wawrzinek R, Wamhoff EC, Lefebre J, Rentzsch M, Bachem G, Domeniconi G et al. A Remote Secondary Binding Pocket Promotes Heteromultivalent Targeting of DC-SIGN. Journal of the American Chemical Society. 2021 Nov 17;143(45):18977-18988. doi: 10.1021/jacs.1c07235

Rentzsch M, Wawrzinek R, Zelle-Rieser C, Strandt H, Bellmann L, Fuchsberger FFR et al. Specific Protein Antigen Delivery to Human Langerhans Cells in Intact Skin. Frontiers in Immunology. 2021 Oct 21;12:732298. doi: 10.3389/fimmu.2021.732298

Fittolani G, Shanina E, Guberman M, Seeberger PH, Rademacher C, Delbianco M. Automated Glycan Assembly of ¹⁹F-labeled Glycan Probes Enables High-Throughput NMR Studies of Protein–Glycan Interactions. Angewandte Chemie - International Edition. 2021 Jun 7;60(24):13302-13309. doi: 10.1002/anie.202102690

Kim D, Rahhal N, Rademacher CJH. Elucidating Carbohydrate-Protein Interactions Using Nanoparticle-Based Approaches. Frontiers in Immunology. 2021 May 11;9:669969. doi: 10.3389/fchem.2021.669969

Kuhaudomlarp S, Siebs E, Shanina E, Topin J, Joachim I, da Silva Figueiredo Celestino Gomes P et al. Non-Carbohydrate Glycomimetics as Inhibitors of Calcium(II)-Binding Lectins. Angewandte Chemie - International Edition. 2021 Apr 6;60(15):8104-8114. doi: 10.1002/anie.202013217

Hendriks A, Van Dalen R, Ali S, Gerlach D, Van Der Marel GA, Fuchsberger FF et al. Impact of Glycan Linkage to Staphylococcus aureus Wall Teichoic Acid on Langerin Recognition and Langerhans Cell Activation. ACS infectious diseases. 2021 Mar 12;7(3):624-635. doi: 10.1021/acsinfecdis.0c00822

Shanina E, Siebs E, Zhang H, Varón Silva D, Joachim I, Titz A et al. Protein-observed 19F NMR of LecA from Pseudomonas aeruginosa. Glycobiology. 2021 Feb 1;31(2):159-165. doi: 10.1093/glycob/cwaa057

Bellmann L, Zelle-Rieser C, Milne P, Resteu A, Tripp CH, Hermann-Kleiter N et al. Notch-Mediated Generation of Monocyte-Derived Langerhans Cells: Phenotype and Function. Journal of Investigative Dermatology. 2021 Jan;141(1):84-94.e6. doi: 10.1016/j.jid.2020.05.098