Einzelansicht Rademacher

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Univ.-Prof. Dr. Christoph Johannes Heinrich Rademacher, B.Sc. M.Sc.

T: +43-1-4277-55578

christoph.rademacher@univie.ac.at

Summer term 2025

301843 UE Practical Course in Molecular and Cellular Immunobiology

322029 VU Ausgewählte Kapitel aus der pharmazeutisch-technologischen Forschung - M13

322575 VO Pharmazeutische Nanotechnologie - Lipid-basierte Applikationen - M7/M14

323104 VU Biophysics in Drug Discovery - MPS5

323151 VU Fragment-based Drug Design - MPS10

Winter term 2024

301817 VO MPM 7 - Lecture course: Model systems in precision medicine - in the context of signature diseases

301818 SE MPM 7 - Seminar, Journal Club and Case Studies: Model systems in precision medicine - in the context of signature diseases

301849 UE Scientific Practice in Molecular Microbiology, Ecology or Immunobiology

322029 VU Ausgewählte Kapitel aus der pharmazeutisch-technologischen Forschung - M13

322072 VO Drug Targeting - Controlled delivery to target tissues - M7/M14

322575 VO Pharmazeutische Nanotechnologie - Lipid-basierte Applikationen - M7/M14

Summer term 2024

301813 VO MPM 3 - Lecture course: Fundamentals of enzymology, diseases and their clinical manifestation - manifestation, and technologies to correct enzymatic insufficiency

301818 VO MPM 7 - Lecture course: Clinical trial design

301843 UE Practical Course in Molecular and Cellular Immunobiology

301861 UE Wahlbeispiel Molekulare Biologie II

322025 VU Ausgewählte Kapitel aus der pharmazeutisch-technologischen Forschung - M13

322575 VO Pharmazeutische Nanotechnologie - Lipid-basierte Applikationen - M7/M14

323104 VU Biophysics in Drug Discovery - MPS5

323151 VU Fragment-based Drug Design - MPS10

Rahhal N, Rentzsch M, Seiser S, Freystätter C, Elbe-Bürger A, Rademacher C. Targeted delivery of cytotoxic proteins via lipid-based nanoparticles to primary Langerhans cells. Nanoscale. 2025 Jan 7. Epub 2025 Jan 7. doi: 10.1039/d4nr03638g

Lefèbre J , Falk T , Ning Y , Rademacher C. Secondary Sites of the C-type Lectin-Like Fold. Chemistry: A European Journal. 2024 May 28;30(30):e202400660. doi: 10.1002/chem.202400660

Leusmann S, Ménová P, Shanin E, Titz A, Rademacher C. Glycomimetics for the inhibition and modulation of lectins. Chemical Society Reviews. 2023 May 26;52(11):3663-3740. doi: 10.1039/d2cs00954d

Fuchsberger FF, Kim D, Baranova N, Vrban H, Kagelmacher M, Wawrzinek R et al. Information transfer in mammalian glycan-based communication. eLife. 2023 Feb 20;12:e69415. doi: 10.7554/eLife.69415

Rademacher CJH. Antigen targeting to dendritic cells: still a place in future immunotherapy? European Journal of Immunology. 2022 Dec;52(12):1909-1924. doi: 10.1002/eji.202149515

Hengxi Z, Modenutti C, Nekkanti YPK, Denis M, Bermejo IA, Lefèbre J et al. Identification of the Allosteric Binding Site for Thiazolopyrimidine on the C-Type Lectin Langerin. ACS Chemical Biology. 2022 Oct 21;17(10):2728–2733. Epub 2022 Sept 26. doi: 10.1021/acschembio.2c00626

Rademacher CJH, Paris G. Automated Laser‐Transfer Synthesis of High‐Density Microarrays for Infectious Disease Screening. Advanced Materials. 2022 Jun 9;34(23):2200359. doi: 10.1002/adma.202200359

Hengxi Z, Daněk O, Makarov D, Rádl S, Kim D, Ledvinka J et al. Drug-like Inhibitors of DC-SIGN Based on a Quinolone Scaffold. ACS Medicinal Chemistry Letters . 2022 Jun 9;13(6):935-942. doi: 10.1021/acsmedchemlett.2c00067

Shanina E, Kuhaudomlarp S, Siebs E, Fuchsberger FFR, Denis M, da Silva Figueiredo Celestino Gomes P et al. Targeting undruggable carbohydrate recognitionsites through focused fragment library design. Communications Chemistry. 2022 May 20;5:64. doi: 10.1038/s42004-022-00679-3

Ghosh C, Priegue P, Leelayuwapan H, Fuchsberger FF, Rademacher CJH, Seeberger PH. Synthetic Glyconanoparticles Modulate Innate Immunity but Not the Complement System. ACS applied bio materials. 2022 Apr 18;5(5):2185-2192. doi: 10.1021/acsabm.2c00026

Rademacher CJH, Siebs E, Shanina E, Kuhaudomlarp S, da Silva Figueiredo Celestino Gomes P, Fortin C et al. Targeting the Central Pocket of the Pseudomonas aeruginosa Lectin LecA. ChemBioChem: a european journal of chemical biology. 2022 Feb 4;23(3):e202100563. Epub 2021 Nov 17. doi: 10.1002/cbic.202100563

Rademacher CJH. Druggable Allosteric Sites in β-Propeller Lectins. Angewandte Chemie (International Edition). 2022 Jan 3;61(1):e202109339. doi: 10.1002/anie.202109339

Rademacher CJH, Wawrzinek R, Wamhoff EC, Lefebre J, Rentzsch M, Bachem G et al. A Remote Secondary Binding Pocket Promotes Heteromultivalent Targeting of DC-SIGN. Journal of the American Chemical Society. 2021 Nov 17;143(45):18977-18988. doi: 10.1021/jacs.1c07235

Rademacher CJH, Rentzsch M, Wawrzinek R, Zelle-Rieser C, Strandt H, Bellmann L et al. Specific Protein Antigen Delivery to Human Langerhans Cells in Intact Skin. Frontiers in Immunology. 2021 Oct 21;12:732298. doi: 10.3389/fimmu.2021.732298

Rademacher CJH. Automated Glycan Assembly of 19 F-labeled Glycan Probes Enables High-Throughput NMR Studies of Protein-Glycan Interactions. Angewandte Chemie (International Edition). 2021 Jun 7;60(24):13302-13309. doi: 10.1002/anie.202102690

Kim D, Rahhal N, Rademacher CJH. Elucidating Carbohydrate-Protein Interactions Using Nanoparticle-Based Approaches. Frontiers in Immunology. 2021 May 11;9:669969. doi: 10.3389/fchem.2021.669969

Joswig JO, Anders J, Zhang H, Rademacher C, Keller BG. The molecular basis for the pH-dependent calcium affinity of the pattern recognition receptor langerin. Journal of Biological Chemistry. 2021;296:100718. doi: 10.1016/j.jbc.2021.100718