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Univ.-Prof. Dr. Christoph Johannes Heinrich Rademacher, B.Sc. M.Sc.
T: +43-1-4277-55578
Winter term 2025
301401 VO Concepts in Molecular Biology
301817 VO MPM 7 - Lecture course: Model systems in precision medicine - in the context of signature diseases
301818 SE MPM 7 - Seminar, Journal Club and Case Studies: Model systems in precision medicine - in the context of signature diseases
301843 UE Practical Course in Molecular and Cellular Immunobiology
301878 PR Advanced Scientific Practice "Immunobiology"
321017 VO Biochemie und Immunologie - B10
322029 VU Ausgewählte Kapitel aus der pharmazeutisch-technologischen Forschung - M13
322072 VO Drug Targeting - Controlled delivery to target tissues - M7/M14
Summer term 2025
301813 VO MPM 3 - Lecture course: Fundamentals of enzymology, diseases and their clinical manifestation - manifestation, and technologies to correct enzymatic insufficiency
301818 VO MPM 7 - Lecture course: Clinical trial design
301843 UE Practical Course in Molecular and Cellular Immunobiology
322029 VU Ausgewählte Kapitel aus der pharmazeutisch-technologischen Forschung - M13
322575 VO Pharmazeutische Nanotechnologie - Lipid-basierte Applikationen - M7/M14
323104 VU Biophysics in Drug Discovery - MPS5
323151 VU Fragment-based Drug Design - MPS10
Winter term 2024
301817 VO MPM 7 - Lecture course: Model systems in precision medicine - in the context of signature diseases
301818 SE MPM 7 - Seminar, Journal Club and Case Studies: Model systems in precision medicine - in the context of signature diseases
301849 UE Scientific Practice in Molecular Microbiology, Ecology or Immunobiology
322029 VU Ausgewählte Kapitel aus der pharmazeutisch-technologischen Forschung - M13
322072 VO Drug Targeting - Controlled delivery to target tissues - M7/M14
322575 VO Pharmazeutische Nanotechnologie - Lipid-basierte Applikationen - M7/M14
1 - 20 out of 63
Lefèbre J, Besch M, Csorba N, Garami K, Orgován Z, Schlosser G et al. Covalent Activation of the C‐type Lectin DC‐SIGN. Angewandte Chemie International Edition. 2025 Nov 24;e20594. doi: 10.1002/anie.202520594
Ning Y, Efrém NL, Amoussa M, Turhan E, Zheng D, Lefèbre J et al. Calcium Competitive Inhibition of Langerin by Thiazolopyrimidinones. Journal of Medicinal Chemistry. 2025 Nov 19. Epub 2025 Nov 19. doi: 10.1021/acs.jmedchem.5c01756
Rica R, Klein K, Johnson L, Carta G, Sarcevic M, Langer F et al. Langerhans cell-targeted protein delivery enhances antigen-specific cellular immune response. Molecular therapy : the journal of the American Society of Gene Therapy. 2025 Oct 4. Epub 2025 Oct 4. doi: 10.1016/j.ymthe.2025.10.008
Lefèbre J, Besch M, Csorba N, Garami K, Orgován Z, Schlosser G et al. Covalent activation of the C-type lectin DC-SIGN. bioRxiv. 2025 Sept 17. doi: 10.1101/2025.09.12.674704
Lefebre J, Besch M, Gamarra MD, Kapp-Joswig JO, Balke A, Flatau H et al. A cryptic pocket allosterically modulates oligosaccharide binding to DC-SIGN. 2025. doi: 10.1101/2025.08.19.671048
Chavan R, Lefèbre J, Jochová K, Dvořáková H, Rademacher C, Ménová P. Fucosyl glycosides for DC-SIGN targeting: Fucosylation strategies, synthesis and binding studies of model compounds. Bioorganic & Medicinal Chemistry. 2025 Jun 1;123:118164. Epub 2025 Mar 20. doi: 10.1016/j.bmc.2025.118164
Chavan R, Besch M, Lefèbre J, Rademacher C, Ménová P. Aryl fucosides: synthesis and evaluation of their binding affinity towards the DC-SIGN receptor. Organic & Biomolecular Chemistry. 2025 Apr 11. doi: 10.1039/D5OB00472A
Rahhal N, Rentzsch M, Seiser S, Freystätter C, Elbe-Bürger A, Rademacher C. Targeted delivery of cytotoxic proteins via lipid-based nanoparticles to primary Langerhans cells. Nanoscale. 2025 Jan 7;17(7):4038-4046. doi: 10.1039/d4nr03638g
Lefèbre J, Falk T, Ning Y, Rademacher C. Secondary Sites of the C-type Lectin-Like Fold. Chemistry: A European Journal. 2024 May 28;30(30):e202400660. doi: 10.1002/chem.202400660
Leusmann S, Ménová P, Shanin E, Titz A, Rademacher C. Glycomimetics for the inhibition and modulation of lectins. Chemical Society Reviews. 2023 May 26;52(11):3663-3740. doi: 10.1039/d2cs00954d
Fuchsberger FF, Kim D, Baranova N, Vrban H, Kagelmacher M, Wawrzinek R et al. Information transfer in mammalian glycan-based communication. eLife. 2023 Feb 20;12:e69415. doi: 10.7554/eLife.69415
Stoitzner P, Romani N, Rademacher CJH, Probst HC, Mahnke K. Antigen targeting to dendritic cells: still a place in future immunotherapy? European Journal of Immunology. 2022 Dec;52(12):1909-1924. doi: 10.1002/eji.202149515
Hengxi Z, Modenutti C, Nekkanti YPK, Denis M, Bermejo IA, Lefèbre J et al. Identification of the Allosteric Binding Site for Thiazolopyrimidine on the C-Type Lectin Langerin. ACS Chemical Biology. 2022 Oct 21;17(10):2728–2733. Epub 2022 Sept 26. doi: 10.1021/acschembio.2c00626
Paris G, Heidepriem J, Tsouka A, Liu Y, Mattes DS, Pinzón Martín S et al. Automated Laser-Transfer Synthesis of High-Density Microarrays for Infectious Disease Screening. Advanced Materials. 2022 Jun 9;34(23):2200359. doi: 10.1002/adma.202200359
Hengxi Z, Daněk O, Makarov D, Rádl S, Kim D, Ledvinka J et al. Drug-like Inhibitors of DC-SIGN Based on a Quinolone Scaffold. ACS Medicinal Chemistry Letters . 2022 Jun 9;13(6):935-942. doi: 10.1021/acsmedchemlett.2c00067
Shanina E, Kuhaudomlarp S, Siebs E, Fuchsberger FFR, Denis M, da Silva Figueiredo Celestino Gomes P et al. Targeting undruggable carbohydrate recognitionsites through focused fragment library design. Communications Chemistry. 2022 May 20;5:64. doi: 10.1038/s42004-022-00679-3
Ghosh C, Priegue P, Leelayuwapan H, Fuchsberger FF, Rademacher CJH, Seeberger PH. Synthetic Glyconanoparticles Modulate Innate Immunity but Not the Complement System. ACS applied bio materials. 2022 Apr 18;5(5):2185-2192. doi: 10.1021/acsabm.2c00026
Siebs E, Shanina E, Kuhaudomlarp S, da Silva Figueiredo Celestino Gomes P, Fortin C, Seeberger PH et al. Targeting the Central Pocket of the Pseudomonas aeruginosa Lectin LecA. ChemBioChem: a european journal of chemical biology. 2022 Feb 4;23(3):e202100563. Epub 2021 Nov 17. doi: 10.1002/cbic.202100563
Shanina E, Kuhaudomlarp S, Lal K, Seeberger PH, Imberty A, Rademacher CJH. Druggable Allosteric Sites in β-Propeller Lectins. Angewandte Chemie (International Edition). 2022 Jan 3;61(1):e202109339. doi: 10.1002/anie.202109339
Wawrzinek R, Wamhoff EC, Lefebre J, Rentzsch M, Bachem G, Domeniconi G et al. A Remote Secondary Binding Pocket Promotes Heteromultivalent Targeting of DC-SIGN. Journal of the American Chemical Society. 2021 Nov 17;143(45):18977-18988. doi: 10.1021/jacs.1c07235
1 - 20 out of 63

Exploring Allosteric Sites in C-Type Lectins to Modulate Their Function

Rademacher, C. J. H. (Speaker)

17 Mar 2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Allosteric Inhibition of C-Type Lectins

Rademacher, C. J. H. (Speaker)

2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Allosteric Inhibition of C-Type Lectins

Rademacher, C. J. H. (Speaker)

2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Cell-specific Targeted Delivery of Therapeutics

Rademacher, C. J. H. (Speaker)

2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Cell-specific transdermal delivery of mRNA and proteins to Langerhans cells

Rademacher, C. J. H. (Speaker)

2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Cell-specific transdermal delivery of mRNA and proteins to Langerhans cells

Rademacher, C. J. H. (Speaker)

2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Development of glycomimetic ligands for C-type lectins and their application for targeted delivery of therapeutics

Rademacher, C. J. H. (Speaker)

2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Discovery and development of small molecule ligands for C-type lectins and their application

Rademacher, C. J. H. (Speaker)

2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Glycomimetic-based Cell-specific Transdermal Delivery of mRNA and Proteins to Langerhans Cells

Rademacher, C. J. H. (Speaker)

2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Glycomimetic-mediated Active Delivery of mRNA and Subunit Transdermal Vaccines

Rademacher, C. J. H. (Speaker)

2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Glycomimetic-mediated targeted delivery to Langerhans cells for transdermal vaccination

Rademacher, C. J. H. (Speaker)

2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Glycomimetic-mediated targeted delivery to Langerhans cells for transdermal vaccination

Rademacher, C. J. H. (Speaker)

2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Secondary Sites and Allosteric Regulation of C-Type Lectins

Rademacher, C. J. H. (Speaker)

2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Small Molecular Modulators of C-type Lectins

Rademacher, C. J. H. (Speaker)

2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Glycomimetic-based delivery of novel transdermal vaccines

Rademacher, C. J. H. (Speaker)

20 Oct 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

NMR Methods in Drug Discovery and Development

Rademacher, C. J. H. (Speaker)

21 Sept 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Glycomimetic Ligands for Mammalian C-type Lectins

Rademacher, C. J. H. (Speaker)

10 Jul 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Information transfer in mammalian glycan-based communication

Rademacher, C. J. H. (Speaker)

Jun 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Targeting Langerhans Cells

Rademacher, C. J. H. (Speaker)

8 Apr 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

From Molecular Drug Targeting to Vaccine Development

Rademacher, C. J. H. (Speaker)

5 Sept 2022

Activity: Talks and presentations › Talk or oral contribution › Science to Science

International Carbohydrate Symposium

Rademacher, C. J. H. (Speaker)

12 Jun 2022

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Applications of Glycomimetics for the Development of Topical Vaccines

Rademacher, C. J. H. (Speaker)

2021

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Carbohydrate Receptor Ligands Enable Targeted Delivery to Immune Cells

Rademacher, C. J. H. (Speaker)

2021

Activity: Talks and presentations › Talk or oral contribution › Science to Science

C-type Lectin Receptors as Drug Targets

Rademacher, C. J. H. (Speaker)

2021

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Glycan-based Cell-Cell Communication – How Lectins Read the Sugar-Code

Rademacher, C. J. H. (Speaker)

2021

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Small Molecule Modulators of C-type Lectin Receptor Functions

Rademacher, C. J. H. (Speaker)

2021

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Cell-type specific targeted delivery of lipid nanoparticles

Rademacher, C. J. H. (Speaker)

30 Jun 0005

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Immuntherapy of cancer with Langerin-ligand liposomes

Rademacher, C. J. H. (Project Lead) & Stoitzner, P. (Project Lead)

Project: Research funding

Anti-Infectives Drug Discovery

Rollinger, J. M. (Project Lead), Dailey, L. A. (Co-Lead), Orts, J. (Co-Lead), Böttcher, T. (Co-Lead), Schmidt, M. (Co-Lead), Rademacher, C. J. H. (Co-Lead), Schützenmeister, N. (Co-Lead), Zotchev, S. (Co-Lead), Kirchmair, J. (Co-Lead) & Ortmayr, K. (Co-Lead)

1/07/25 → 30/06/29

Project: Research funding

AUREUS: wAll teichoic acids as immUnogenic and conseRved altErnative targets for therapies versUs S. aureus

Rademacher, C. J. H. (Project Lead)

1/02/25 → 31/01/29

Project: Research funding

TargetCLEC2: Modulation of platelet biology with CLEC-2 targeted liposomes

Rademacher, C. J. H. (Project Lead), Pfrengle, F. (Co-Lead) & Eichinger, S. (Co-Lead)

1/06/22 → 30/11/25

Project: Research funding

Allostery in Drug Discovery

Rademacher, C. J. H. (Project Lead)

1/09/21 → 31/08/25

Project: Research funding

GLYCONOISE: Emergent properties of cell surface glycosylation in cell-cell communication

Rademacher, C. J. H. (Project Lead)

1/09/20 → 31/01/23

Project: Research funding

Targeted Antigen deLivery to Langerin: molecular basis of recognition and its implication in antigen uptake, processing and presentation to T cells

Rademacher, C. J. H. (Project Lead) & Bermejo, I. A. (Co-Lead)

1/09/20 → 30/06/23

Project: Research funding

Department of Pharmaceutical Sciences

Josef-Holaubek-Platz 2 (UZA II)
1090 Wien
Room: 2E449B

T: +43-1-4277-55578

christoph.rademacher@univie.ac.at