Research

Systems Biology of Pain

Research in our laboratory is driven by our motivation to decipher the dynamics of protein networks underlying vertebrate somatosensation in health, development (aging) and disease (chronic pain). Methodologically, we combine molecular biology, biochemistry and latest proteomics techniques, electrophysiology, pharmacology, mouse models of painful pathologies and in vivo virus-mediated gene transfer.

This multidisciplinary approach has enabled us to reveal ion channel-associated signaling complexes (i.e. the interactome of TRPV1, TRPA1 and Piezo2 channels) with pathological relevance for pain. Moreover, in a quantitative systems biology approach, we investigate spatiotemporal proteome dynamics both in mice and humans. Our research lives from our fruitful collaborations with basic researchers and clinicians alike facilitating forward and reverse translation of our research results.

In this way we strive to gain mechanistic insights into developmental and pain-associated plasticity – an endevour, which lies at the heart of both understanding the molecular signature of chronic pain and identifying novel drug targets.

Publications:

• ORCID 0000-0003-1972-3519
• PubMed-NCBI 
• u:cris