Research

Thesis title: Role of Toll-like Receptors in the Development of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Thesis outline:

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), previously known as Non-Alcoholic Fatty Liver Disease (NAFLD), is the most common chronic liver condition globally by now. Its progression is largely driven by factors such as obesity, metabolic syndrome, and inflammation.

In addition to overnutrition and insulin resistance, studies suggest that alteration of gut microbiota and compromised intestinal barrier function play a significant role in the development of MASLD. The gut microbiota interacts with the immune system by producing metabolites and molecular patterns that are recognized by Toll-like receptors (TLRs). These receptors initiate immune responses that are crucial for maintaining intestinal balance but may also contribute to MASLD when dysregulated.

However, the interplay between TLR activation, changes in gut microbiota, and dietary factors and their contribution to MASLD development have not yet been clarified.

The primary aim of this doctoral project is to investigate whether the development of MASLD in humans is linked to specific intestinal microbiota compositions, TLR ligand profiles, and the contribution of dietary patterns herein. Moreover, the immune responsiveness of blood immune cells in individuals with MASLD will be assessed.

Supervisor: Ina Bergheim, Advisor: Amélia Camarinha-Silva (University of Hohenheim)

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