Michael Netzer


Thesis title: "Electrophysiological characterization and proof of principle cardiotoxicity screenings of cardioids"

Thesis outline: Evaluating drugs’ potential cardiotoxicity is highly challenging, mainly due to a lack of appropriate in vitro drug test systems. Therefore, we aim to establish and further develop a novel, completely non-invasive drug screening method based on an optical acquisition system capable of measuring intracellular action potentials. Validation of this method will be enabled by comparison with manual and automated patch clamp, as well as fluorescence imaging techniques. Additionally, stem cell derived 3D cardiac organoids will be electrophysiologically characterized and employed for drug screening to further advance this next generation method.

Supervisor: Steffen Hering, Advisor: Marcel AG van der Heyden