Research

Thesis title: "Discovery and Characterisation of Natural Products as Ligands for Nuclear Receptors using Experimental and In Silico Approaches"

Thesis outline: Nuclear receptors are ligand-dependent transcription factors that link signals from extracellular signalling molecules with gene expression patterns. By binding regulatory elements on the DNA, they orchestrate the transcription of target genes, thus influencing several important biological processes such as development, reproduction, inflammation and metabolism. The discovery and characterisation of natural products as novel ligands for nuclear receptors would contribute to the development of new drugs.

Funding: University Asisstant (predoctoral)

Supervisor: Verena Dirsch

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