Heterologous Expression and CRISPR/Cas9-Assisted Manipulation of the Hybrid Gene Cluster Specifying the Biosynthesis of Meroterpenoids and Phenazines

Schneider, O., Zehl, M., Miele, M., Pace, V., Brungs, C., Cheng, J.-F., Hummelbrunner, S., Dirsch, V. M. & Zotchev, S. B. (Corresponding author), 2026, In: ACS Synthetic Biology. 15, p. 137-148 PMID: 41433963.

Genome mining of Streptomyces bambergiensis AC-800 unravels the biosynthetic gene cluster for inhibitors of prolyl hydroxylase fibrostatins

Guerrero Garzón, J. F., Zehl, M., Schneider, O., Marquez, I. T., Rückert-Reed, C., Kalinowski, J. & Zotchev, S. B. (Corresponding author), 1 Sept 2025, In: Scientific Reports. 15, 1, 32142.

The bacterial community of the freshwater bryozoan Cristatella Mucedo and its secondary metabolites production potential

Tocino-Márquez, I., Zehl, M., Séneca Cardoso Da Silva, J., Pjevac, P., Felkl, M., Becker, C. F. W., Loy, A., Rattei, T., Ostrovsky, A. N. & Zotchev, S. B. (Corresponding author), 26 Aug 2025, In: Scientific Reports. 15, 1, 31456.

Saarvienin A - A Novel Glycopeptide with Potent Activity against Drug-resistant Bacteria

Kaur, A., Guerrero-Garzón, J. F., Rasheed, S., Zehl, M., Fries, F., Morgenstern, B., Zotchev, S. B. (Corresponding author) & Müller, R. (Corresponding author), 17 Jun 2025, In: Angewandte Chemie (International ed. in English). 64, 25, e202425588.

Secondary Metabolite Biosynthesis Potential of Streptomyces Spp. from the Rhizosphere of Leontopodium nivale Subsp. alpinum

Vignolle, A., Zehl, M., Kirkegaard, R. H., Vignolle, G. A. & Zotchev, S. B. (Corresponding author), 25 Feb 2025, In: ACS Omega. 10, 7, p. 7163-7171 9 p.

Deletions of conserved extracytoplasmic function sigma factors-encoding genes in Streptomyces have a major impact on secondary metabolism

Sekurova, O. N., Zehl, M., Predl, M., Hunyadi, P., Rattei, T. & Zotchev, S. B. (Corresponding author), 18 Jul 2024, In: Microbial Cell Factories. 23, 1, 201.

Genomes and secondary metabolomes of Streptomyces spp. isolated from Leontopodium nivale ssp. alpinum

Malfent, F., Zehl, M., Kirkegaard, R. H., Oberhofer, M. & Zotchev, S. (Corresponding author), 14 Jun 2024, In: Frontiers in Microbiology. 15, 1408479.

Impact of Phylogenetically Diverse Bacterial Endophytes of Bergenia pacumbis on Bergenin Production in the Plant Cell Suspension Cultures

Wawrosch, C., Oberhofer, M., Steinbrecher, S. & Zotchev, S. B., 6 Jun 2024, In: Planta Medica. 90, 7-8, p. 651-657 7 p.

Unlocking the potential of bacterial endophytes from medicinal plants for drug discovery

Zotchev, S. B. (Corresponding author), Feb 2024, In: Microbial Biotechnology. 17, 2, e14382.

Discovery of novel natural products from endophytic Streptomyces spp. isolated from Leontopodium nivale ssp. alpinum

Malfent, F., Niedermayr, V., Oberhofer, M., Zehl, M., Pjevac, P. & Zotchev, S., Nov 2023, In: Planta Medica. 89, 14, p. 1318-1318 P-053.

Streptomyces spp. from the rhizosphere of Leontopodium nivale subsp. alpinum - uncovering potential for the biosynthesis of secondary metabolites

Vignolle, A., Zehl, M., Pjevac, P. & Zotchev, S., Nov 2023, In: Planta Medica. 89, 14, p. 1361-1361 P-196.

Secondary Metabolite Production Potential in a Microbiome of the Freshwater Sponge Spongilla lacustris

Graffius, S., Garzón, J. F. G., Zehl, M., Pjevac, P., Kirkegaard, R., Flieder, M., Loy, A., Rattei, T., Ostrovsky, A. & Zotchev, S. B., 13 Apr 2023, In: Microbiology Spectrum. 11, 2, e04353-22.

Developing co-cultures of bacterial isolates from the bryozoan Cristatella mucedo for the discovery of novel secondary metabolites

Tocino Márquez, I., Zehl, M., Pjevac, P., Kirkegaard, R., Flieder, M., Loy, A., Rattei, T. & Zotchev, S., Dec 2022, In: Planta Medica. 88, 15, p. 1438-1438 1 p.

Targeted Metabolomics and High-Throughput RNA Sequencing-Based Transcriptomics Reveal Massive Changes in the Streptomyces venezuelae NRRL B-65442 Metabolism Caused by Ethanol Shock

Sekurova, O. N., Zehl, M., Predl, M., Hunyadi, P., Rattei, T. & Zotchev, S. B. (Corresponding author), 31 Oct 2022, In: Microbiology Spectrum. 10, 6, 19 p., e0367222.

N-Succinyltransferase Encoded by a Cryptic Siderophore Biosynthesis Gene Cluster in Streptomyces Modifies Structurally Distinct Antibiotics

Schneider, O., Zehl, M., Ueoka, R., Rückert, C., Buche, T., Jiang, Y., Li, Q.-Y., Piel, J. & Zotchev, S. B. (Corresponding author), 26 Oct 2022, In: mBio. 13, 5, 15 p., e0178922.

Biosynthetic Potential of the Endophytic Fungus Helotiales sp. BL73 Revealed via Compound Identification and Genome Mining

Oberhofer, M., Malfent, F., Zehl, M., Urban, E., Wackerlig, J., Reznicek, G., Vignolle, G. A., Rückert, C., Busche, T., Wibberg, D. & Zotchev, S. B. (Corresponding author), Mar 2022, In: Applied and Environmental Microbiology. 88, 6, 13 p., e02510-21.

Production of bioactive plant secondary metabolites through in vitro technologies-status and outlook

Wawrosch, C. (Corresponding author) & Zotchev, S. B., 1 Sept 2021, (E-pub ahead of print) In: Applied Microbiology and Biotechnology. 105, 18, p. 6649-6668 20 p.

Coupling of the engineered DNA "mutator" to a biosensor as a new paradigm for activation of silent biosynthetic gene clusters in Streptomyces

Sekurova, O. N., Sun, Y.-Q., Zehl, M., Rueckert, C., Stich, A., Busche, T., Kalinowski, J. & Zotchev, S. B. (Corresponding author), 20 Aug 2021, In: Nucleic Acids Research. 49, 14, p. 8396-8405 10 p.

Natural products in drug discovery: advances and opportunities

Atanasov, A. G. (Corresponding author), Zotchev, S. B., Dirsch, V. M., the International Natural Product Sciences Taskforce & Supuran, C. T. (Corresponding author), Mar 2021, In: Nature Reviews Drug Discovery. 20, p. 200-216 17 p.

Endophytic Akanthomyces sp. LN303 from Edelweiss Produces Emestrin and Two New 2-Hydroxy-4 Pyridone Alkaloids

Oberhofer, M. (Corresponding author), Wackerlig, J., Zehl, M., Buyuk, H., Cao, J., Prado-Roller, A., Urban, E. & Zotchev, S. B., 26 Jan 2021, In: ACS Omega. 6, 3, p. 2184-2191 8 p.

Piperazic acid containing peptides produced by an endophytic Streptomyces sp. isolated from the medicinal plant Atropa belladonna

Bekiesch, P. (Corresponding author), Oberhofer, M., Sykora, C., Urban, E. & Zotchev, S., 2021, In: Natural Product Research. 35, 7, p. 1090-1096 7 p.

Class IV Lasso Peptides Synergistically Induce Proliferation of Cancer Cells and Sensitize Them to Doxorubicin

Guerrero-Garzón, J. F., Madland, E., Zehl, M., Singh, M., Rezaei, S., Aachmann, F. L., Courtade, G., Urban, E., Rückert, C., Busche, T., Kalinowski, J., Cao, Y. R., Jiang, Y., Jiang, C. L., Selivanova, G. (Corresponding author) & Zotchev, S. B. (Corresponding author), 18 Dec 2020, In: Iscience. 23, 12, 41 p., 101785.

Viennamycins: Lipopeptides Produced by a Streptomyces sp

Bekiesch, P., Zehl, M., Domingo-Contreras, E., Martín, J., Pérez-Victoria, I., Reyes, F., Kaplan, A., Rückert, C., Busche, T., Kalinowski, J. & Zotchev, S. B. (Corresponding author), 28 Aug 2020, In: Journal of Natural Products. 83, 8, p. 2381–2389 9 p.

Streptomyces spp. From the Marine Sponge Antho dichotoma: Analyses of Secondary Metabolite Biosynthesis Gene Clusters and Some of Their Products

Guerrero-Garzón, J. F., Zehl, M., Schneider, O., Rückert, C., Busche, T., Kalinowski, J., Bredholt, H. & Zotchev, S. B. (Corresponding author), 18 Mar 2020, In: Frontiers in Microbiology. 11, p. 437 15 p., 437.

Corrigendum: Prauserella flavalba sp. nov., a novel species of the genus Prauserella, isolated from alkaline soil (vol 70, pg 380, 2020)

Li, Q., Rückert, C., Li, G., Huang, P., Schneider, O., Kalinowski, J., Jiang, Y., Zotchev, S. B. & Jiang, C. L., 1 Jan 2020, In: International Journal of Systematic and Evolutionary Microbiology. 70, 1, p. 703-703 1 p., 003886.

Prauserella flavalba sp. nov., a novel species of the genus Prauserella, isolated from alkaline soil

Li, Q., Rückert, C., Li, G., Huang, P., Schneider, O., Kalinowski, J., Jiang, Y., Zotchev, S. B. & Jiang, C., 2020, In: International Journal of Systematic and Evolutionary Microbiology. 70, 1, p. 380-387 8 p., 003768.

Exploring Actinobacteria Associated With Rhizosphere and Endosphere of the Native Alpine Medicinal Plant Leontopodium nivale Subspecies alpinum

Oberhofer, M., Hess, J., Leutgeb, M., Gössnitzer, F., Rattei, T., Wawrosch, C. & Zotchev, S. B., 8 Nov 2019, In: Frontiers in Microbiology. 10, 13 p., 2531.

Novel bioactive natural products from bacteria via bioprospecting, genome mining and metabolic engineering

Sekurova, O. N., Schneider, O. & Zotchev, S. B., Sept 2019, In: Microbial Biotechnology. 12, 5, p. 828-844 17 p.

Noursamycins, Chlorinated Cyclohexapeptides Identified from Molecular Networking of Streptomyces noursei NTR-SR4

Mudalungu, C. M., Törne, W. J. V., Voigt, K., Rückert, C., Schmitz, S., Sekurova, O. N., Zotchev, S. B. & Süssmuth, R. D., 7 Jun 2019, In: Journal of Natural Products. 82, 6, p. 1478-1486 9 p.

Genome Mining of Streptomyces sp. YIM 130001 Isolated From Lichen Affords New Thiopeptide Antibiotic

Schneider, O., Simic, N., Aachmann, F. L., Rueckert, C., Kristiansen, K. A., Kalinowski, J., Jiang, Y., Wang, L., Jiang, C.-L., Lale, R. & Zotchev, S. B. (Corresponding author), 19 Dec 2018, In: Frontiers in Microbiology. 9, 12 p., 3139.

Genomics-based insights into the biosynthesis and unusually high accumulation of free fatty acids by Streptomyces sp. NP10

Schneider, O., Ilic-Tomic, T., Rückert, C., Kalinowski, J., Gencic, M. S., Živković, M. Z., Stankovic, N., Radulović, N. S., Vasiljevic, B., Nikodinovic-Runic, J. (Corresponding author) & Zotchev, S. B. (Corresponding author), 19 Jun 2018, In: Frontiers in Microbiology. 9, 10 p., 1302.

Streptomyces spp. From Ethiopia producing antimicrobial compounds: Characterization via bioassays, genome analyses, and mass spectrometry

Kibret, M., Guerrero-Garzón, J. F., Urban, E., Zehl, M., Wronski, V. K., Rückert, C., Busche, T., Kalinowski, J., Rollinger, J. M., Abate, D. & Zotchev, S. B. (Corresponding author), 12 Jun 2018, In: Frontiers in Microbiology. 9, 13 p., 1270.

An orthogonal system for heterologous expression of actinobacterial lasso peptides in Streptomyces hosts

Mevaere, J., Goulard, C., Schneider, O., Sekurova, O. N., Ma, H., Zirah, S., Afonso, C., Rebuffat, S., Zotchev, S. B. & Li, Y., 2018, In: Scientific Reports. 8, 1, 11 p., 8232.

Micropropagation and cryoconservation of the endangered plant species Artemisia laciniata (Asteraceae).

Kodym, A., Senula, A., Temsch, E., Hood-Novotny, R., Schumacher, F., Sekurova, O., Zotchev, S. & Kiehn, M., 2018, In: CryoLetters. 39, 3, p. 177-189

Actinoalloteichus fjordicus sp. nov. isolated from marine sponges: phenotypic, chemotaxonomic and genomic characterisation

Nouioui, I., Rückert, C., Willemse, J., van Wezel, G. P., Klenk, H. P., Busche, T., Kalinowski, J., Bredholt, H. & Zotchev, S. B. (Corresponding author), Dec 2017, In: Antonie van Leeuwenhoek: international journal of general and molecular microbiology. 110, 12, p. 1705–1717 13 p.

Development of a Biosensor Concept to Detect the Production of Cluster-Specific Secondary Metabolites

Sun, Y.-Q., Busche, T., Rückert, C., Paulus, C., Rebets, Y., Novakova, R., Kalinowski, J., Luzhetskyy, A., Kormanec, J., Sekurova, O. N. & Zotchev, S. B. (Corresponding author), 16 Jun 2017, In: ACS Synthetic Biology. 6, 6, p. 1026–1033 8 p.

New natural products identified by combined genomics-metabolomics profiling of marine Streptomyces sp. MP131-18

Paulus, C., Rebets, Y., Tokovenko, B., Nadmid, S., Terekhova, L. P., Myronovskyi, M., Zotchev, S. B., Rückert, C., Braig, S., Zahler, S., Kalinowski, J. & Luzhetskyy, A., 10 Feb 2017, In: Scientific Reports. 7, 11 p., 42382.

Complete genome sequence of the actinomycete Actinoalloteichus hymeniacidonis type strain HPA 177(T) isolated from a marine sponge

Schaffert, L., Albersmeier, A., Winkler, A., Kalinowski, J., Zotchev, S. B. & Rückert, C., 20 Dec 2016, In: Standards in Genomic Sciences. 11, p. 91 8 p., 91.

New Deferoxamine Glycoconjugates Produced upon Overexpression of Pathway-Specific Regulatory Gene in the Marine Sponge-Derived Streptomyces albus PVA94-07

Sekurova, O. N., Pérez-Victoria, I., Martín, J., Degnes, K. F., Sletta, H., Reyes, F. & Zotchev, S. B. (Corresponding author), Sept 2016, In: Molecules. 21, 9, 14 p., 1131.

Cloning and Heterologous Expression of the Grecocycline Biosynthetic Gene Cluster

Bilyk, O., Sekurova, O. N., Zotchev, S. B. & Luzhetskyy, A. (Corresponding author), 13 Jul 2016, In: PLoS ONE. 11, 7, p. e0158682 17 p., e0158682.

Activation of chloramphenicol biosynthesis in Streptomyces venezuelae ATCC 10712 by ethanol shock: insights from the promoter fusion studies

Sekurova, O. N., Zhang, J., Kristiansen, K. A. & Zotchev, S. B. (Corresponding author), 20 May 2016, In: Microbial Cell Factories. 15, p. 85 10 p., 85.

Minimum Information about a Biosynthetic Gene cluster

Medema, M. H., Kottmann, R., Yilmaz, P., Cummings, M., Biggins, J. B., Blin, K., de Bruijn, I., Chooi, Y. H., Claesen, J., Coates, R. C., Cruz-Morales, P., Duddela, S., Duesterhus, S., Edwards, D. J., Fewer, D. P., Garg, N., Geiger, C., Gomez-Escribano, J. P., Greule, A. & Hadjithomas, M. & 134 others, Haines, A. S., Helfrich, E. J. N., Hillwig, M. L., Ishida, K., Jones, A. C., Jones, C. S., Jungmann, K., Kegler, C., Kim, H. U., Koetter, P., Krug, D., Masschelein, J., Melnik, A. V., Mantovani, S. M., Monroe, E. A., Moore, M., Moss, N., Nuetzmann, H.-W., Pan, G., Pati, A., Petras, D., Reen, F. J., Rosconi, F., Rui, Z., Tian, Z., Tobias, N. J., Tsunematsu, Y., Wiemann, P., Wyckoff, E., Yan, X., Yim, G., Yu, F., Xie, Y., Aigle, B., Apel, A. K., Balibar, C. J., Balskus, E. P., Barona-Gomez, F., Bechthold, A., Bode, H. B., Borriss, R., Brady, S. F., Brakhage, A. A., Caffrey, P., Cheng, Y.-Q., Clardy, J., Cox, R. J., De Mot, R., Donadio, S., Donia, M. S., van der Donk, W. A., Dorrestein, P. C., Doyle, S., Driessen, A. J. M., Ehling-Schulz, M., Entian, K.-D., Fischbach, M. A., Gerwick, L., Gerwick, W. H., Gross, H., Gust, B., Hertweck, C., Hofte, M., Jensen, S. E., Ju, J., Katz, L., Kaysser, L., Klassen, J. L., Keller, N. P., Kormanec, J., Kuipers, O. P., Kuzuyama, T., Kyrpides, N. C., Kwon, H.-J., Lautru, S., Lavigne, R., Lee, C. Y., Linquan, B., Liu, X., Liu, W., Luzhetskyy, A., Mahmud, T., Mast, Y., Mendez, C., Metsa-Ketela, M., Micklefield, J., Mitchell, D. A., Moore, B. S., Moreira, L. M., Mueller, R., Neilan, B. A., Nett, M., Nielsen, J., O'Gara, F., Oikawa, H., Osbourn, A., Osburne, M. S., Ostash, B., Payne, S. M., Pernodet, J.-L., Petricek, M., Piel, J., Ploux, O., Raaijmakers, J. M., Salas, J. A., Schmitt, E. K., Scott, B., Seipke, R. F., Shen, B., Sherman, D. H., Sivonen, K., Smanski, M. J., Sosio, M., Stegmann, E., Suessmuth, R. D., Tahlan, K., Thomas, C. M., Tang, Y., Truman, A. W., Viaud, M., Walton, J. D., Walsh, C. T., Weber, T., van Wezel, G. P., Wilkinson, B., Willey, J. M., Wohlleben, W., Wright, G. D., Ziemert, N., Zhang, C., Zotchev, S. B., Breitling, R., Takano, E. & Gloeckner, F. O., 18 Aug 2015, In: Nature Chemical Biology. 11, 9, p. 625-631 7 p.

Engineering Terpene Biosynthesis in Streptomyces for Production of the Advanced Biofuel Precursor Bisabolene

Phelan, R. M., Sekurova, O. N., Keasling, J. D. & Zotchev, S. B., Apr 2015, In: ACS Synthetic Biology. 4, 4, p. 393-399 7 p.

Genomics of Sponge-Associated Streptomyces spp. Closely Related to Streptomyces albus J1074: Insights into Marine Adaptation and Secondary Metabolite Biosynthesis Potential

Ian, E., Malko, D. B., Sekurova, O. N., Bredholt, H., Rueckert, C., Borisova, M. E., Albersmeier, A., Kalinowski, J., Gelfand, M. S. & Zotchev, S. B., 12 May 2014, In: PLoS ONE. 9, 5, 11 p., e96719.

Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp DSM 45942 isolated from the fjord sediment

Sletta, H., Degnes, K. F., Herfindal, L., Klinkenberg, G., Fjaervik, E., Zahlsen, K., Brunsvik, A., Nygaard, G., Aachmann, F. L., Ellingsen, T. E., Doskeland, S. O. & Zotchev, S. B., Jan 2014, In: Applied Microbiology and Biotechnology. 98, 2, p. 603-610 8 p.

Structure-Antifungal Activity Relationships of Polyene Antibiotics of the Amphotericin B Group

Tevyashova, A. N., Olsufyeva, E. N., Solovieva, S. E., Printsevskaya, S. S., Reznikova, M. I., Trenin, A. S., Galatenko, O. A., Treshalin, I. D., Pereverzeva, E. R., Mirchink, E. P., Isakova, E. B., Zotchev, S. B. & Preobrazhenskaya, M. N., Aug 2013, In: Antimicrobial Agents and Chemotherapy. 57, 8, p. 3815-3822 8 p.

Genome-based bioprospecting of microbes for new therapeutics

Zotchev, S. B., Sekurova, O. N. & Katz, L., Dec 2012, In: Current Opinion in Biotechnology. 23, 6, p. 941-947 7 p.

Marine actinomycetes as an emerging resource for the drug development pipelines

Zotchev, S. B., 30 Apr 2012, In: Journal of Biotechnology. 158, 4, p. 168-175 8 p.

Initiation of Polyene Macrolide Biosynthesis: Interplay between Polyketide Synthase Domains and Modules as Revealed via Domain Swapping, Mutagenesis, and Heterologous Complementation

Heia, S., Borgos, S. E. F., Sletta, H., Escudero, L., Seco, E. M., Malpartida, F., Ellingsen, T. E. & Zotchev, S. B., Oct 2011, In: Applied and Environmental Microbiology. 77, 19, p. 6982-6990 9 p.

New Nystatin-Related Antifungal Polyene Macrolides with Altered Polyol Region Generated via Biosynthetic Engineering of Streptomyces noursei

Brautaset, T., Sletta, H., Degnes, K. F., Sekurova, O. N., Bakke, I., Volokhan, O., Andreassen, T., Ellingsen, T. E. & Zotchev, S. B., Sept 2011, In: Applied and Environmental Microbiology. 77, 18, p. 6636-6643 8 p.

Weaving a synthetic harness for the biosynthesis of natural products

Zotchev, S. B., Mar 2011, In: Microbial Biotechnology. 4, 2, p. 135-137 3 p.

Isolation and Characterization of the Gene Cluster for Biosynthesis of the Thiopeptide Antibiotic TP-1161

Engelhardt, K., Degnes, K. F. & Zotchev, S. B., Nov 2010, In: Applied and Environmental Microbiology. 76, 21, p. 7093-7101 9 p.

Production of a New Thiopeptide Antibiotic, TP-1161, by a Marine Nocardiopsis Species

Engelhardt, K., Degnes, K. F., Kemmler, M., Bredholt, H., Fjaervik, E., Klinkenberg, G., Sletta, H., Ellingsen, T. E. & Zotchev, S. B., Aug 2010, In: Applied and Environmental Microbiology. 76, 15, p. 4969-4976 8 p.

Synthesis and study of the antifungal activity of new mono- and disubstituted derivatives of a genetically engineered polyene antibiotic 28,29-didehydronystatin A(1) (S44HP)

Preobrazhenskaya, M. N., Olsufyeva, E. N., Tevyashova, A. N., Printsevskaya, S. S., Solovieva, S. E., Reznikova, M. I., Trenin, A. S., Galatenko, O. A., Treshalin, I. D., Pereverzeva, E. R., Mirchink, E. P. & Zotchev, S. B., Feb 2010, In: Journal of Antibiotics. 63, 2, p. 55-64 10 p.

Insights into the Evolution of Macrolactam Biosynthesis through Cloning and Comparative Analysis of the Biosynthetic Gene Cluster for a Novel Macrocyclic Lactam, ML-449

Jorgensen, H., Degnes, K. F., Dikiy, A., Fjaervik, E., Klinkenberg, G. & Zotchev, S. B., Jan 2010, In: Applied and Environmental Microbiology. 76, 1, p. 283-293 11 p.

Violacein-Producing Collimonas sp from the Sea Surface Microlayer of Costal Waters in Trondelag, Norway

Hakvag, S., Fjaervik, E., Klinkenberg, G., Borgos, S. E. F., Josefsen, K. D., Ellingsen, T. E. & Zotchev, S. B., Dec 2009, In: Marine Drugs. 7, 4, p. 576-588 13 p.

Biosynthesis of Macrolactam BE-14106 Involves Two Distinct PKS Systems and Amino Acid Processing Enzymes for Generation of the Aminoacyl Starter Unit

Jorgensen, H., Degnes, K. F., Sletta, H., Fjaervik, E., Dikiy, A., Herfindal, L., Bruheim, P., Klinkenberg, G., Bredholt, H., Nygard, G., Doskeland, S. O., Ellingsen, T. E. & Zotchev, S. B., 30 Oct 2009, In: Chemistry & Biology. 16, 10, p. 1109-1121 13 p.

Candicidin Biosynthesis Gene Cluster Is Widely Distributed among Streptomyces spp. Isolated from the Sediments and the Neuston Layer of the Trondheim Fjord, Norway

Jorgensen, H., Fjaervik, E., Hakvag, S., Bruheim, P., Bredholt, H., Klinkenberg, G., Ellingsen, T. E. & Zotchev, S. B., 15 May 2009, In: Applied and Environmental Microbiology. 75, 10, p. 3296-3303 8 p.

Chemical Modification and Biological Evaluation of New Semisynthetic Derivatives of 28,29-Didehydronystatin A(1) (S44HP), a Genetically Engineered Antifungal Polyene Macrolide Antibiotic

Preobrazhenskaya, M. N., Olsufyeva, E. N., Solovieva, S. E., Tevyashova, A. N., Reznikova, M. I., Luzikov, Y. N., Terekhova, L. P., Trenin, A. S., Galatenko, O. A., Treshalin, I. D., Mirchink, E. P., Bukhman, V. M., Sletta, H. & Zotchev, S. B., 8 Jan 2009, In: Journal of Medicinal Chemistry. 52, 1, p. 189-196 8 p.

Characterization of Streptomyces spp. Isolated from the Sea Surface Microlayer in the Trondheim Fjord, Norway

Hakvag, S., Fjaervik, E., Josefsen, K. D., Ian, E., Ellingsen, T. E. & Zotchev, S. B., Dec 2008, In: Marine Drugs. 6, 4, p. 620-635 16 p.

Improved Antifungal Polyene Macrolides via Engineering of the Nystatin Biosynthetic Genes in Streptomyces noursei

Brautaset, T., Sletta, H., Nedal, A., Borgos, S. E. F., Degnes, K. F., Bakke, I., Volokhan, O., Sekurova, O. N., Treshalin, I. D., Mirchink, E. P., Dikiy, A., Ellingsen, T. E. & Zotchev, S. B., 24 Nov 2008, In: Chemistry & Biology. 15, 11, p. 1198-1206 9 p.

Biosynthesis of natural products applied to drug discovery

Zotchev, S. B., May 2008, In: Current Topics in Medicinal Chemistry. 8, 8, p. 616-617 2 p.

Biosynthetic engineering of polyene macrolides towards generation of improved antifungal and antiparasitic agents

Caffrey, P., Aparicio, J. F., Malpartida, F. & Zotchev, S. B., May 2008, In: Current Topics in Medicinal Chemistry. 8, 8, p. 639-653 15 p.

Actinomycetes from Sediments in the trondheim fjord, Norway: Diversity and biological activity

Bredholt, H., Fjaervik, E., Johnsen, G. & Zotchev, S. B., Mar 2008, In: Marine Drugs. 6, 1, p. 12-24 13 p.

Computer-aided design of polyketides with the required properties

Sergeyko, A. P., Stepanchikova, A. V., Sobolev, B. N., Zotchev, S. B., Lagunin, A. A., Filimonov, D. A. & Poroikov, V. V., Mar 2008, In: Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 2, 1, p. 55-62 8 p.

Analysis of the mycosamine biosynthesis and attachment genes in the nystatin Biosynthetic gene cluster of Streptomyces noursei ATCC 11455

Nedal, A., Sletta, H., Brautaset, T., Borgos, S. E. F., Sekurova, O. N., Ellingsen, T. E. & Zotchev, S. B., Nov 2007, In: Applied and Environmental Microbiology. 73, 22, p. 7400-7407 8 p.

Rare actinomycete bacteria from the shallow water sediments of the Trondheim fjord, Norway: isolation, diversity and biological activity

Bredholdt, H., Galatenko, O. A., Engelhardt, K., Fjaervik, E., Terekhova, L. P. & Zotchev, S. B., Nov 2007, In: Environmental Microbiology. 9, 11, p. 2756-2764 9 p.

Bacterial metabolism of long-chain n-alkanes

Wentzel, A., Ellingsen, T. E., Kotlar, H.-K., Zotchev, S. B. & Throne-Holst, M., Oct 2007, In: Applied Microbiology and Biotechnology. 76, 6, p. 1209-1221 13 p.

Identification of novel genes involved in long-chain n-alkane degradation by Acinetobacter sp strain DSM 17874

Throne-Holst, M., Wentzel, A., Ellingsen, T. E., Kotlar, H.-K. & Zotchev, S. B., May 2007, In: Applied and Environmental Microbiology. 73, 10, p. 3327-3332 6 p.

Computer-aided design of polyketides with the required properties

Sergeyko, A. P., Stepanchikova, A. V., Sobolev, B. N., Zotchev, S. B., Lagunin, A. A., Filimonov, D. A. & Poroikov, V. V., 2007, In: Biomeditsinskaya Khimiya. 53, 5, p. 522-531 10 p.

Utilization of n-alkanes by a newly isolated strain of Acinetobacter venetianus: the role of two AlkB-type alkane hydroxylases

Throne-Holst, M., Markussen, S., Winnberg, A., Ellingsen, T. E., Kotlar, H.-K. & Zotchev, S. B., Sept 2006, In: Applied Microbiology and Biotechnology. 72, 2, p. 353-360 8 p.

Probing the structure-function relationship of polyene macrolides: Engineered biosynthesis of soluble nystatin analogues

Borgos, S., Tsan, P., Sletta, H., Ellingsen, T., Lancelin, J. & Zotchev, S., 20 Apr 2006, In: Journal of Medicinal Chemistry. 49, 8, p. 2431-2439 9 p.

Characterization of the P450 monooxygenase NysL, responsible for C-10 hydroxylation during biosynthesis of the polyene macrolide antibiotic nystatin in Streptomyces noursei

Volokhan, O., Sletta, H., Ellingsen, T. & Zotchev, S., Apr 2006, In: Applied and Environmental Microbiology. 72, 4, p. 2514-2519 6 p.

Effect of glucose limitation and specific mutations in the module 5 enoyl reductase domains in the nystatin and amphotericin polyketide synthases on polyene macrolide biosynthesis

Borgos, S., Sletta, H., Fjaervik, E., Brautaset, T., Ellingsen, T., Gulliksen, O. & Zotchev, S., Apr 2006, In: Archives of Microbiology. 185, 3, p. 165-171 7 p.

Rational design of macrolides by virtual screening of combinatorial libraries generated through in silico manipulation of polyketide synthases

Zotchev, S., Stepanchikova, A., Sergeyko, A., Sobolev, B., Filimonov, D. & Poroikov, V., 23 Mar 2006, In: Journal of Medicinal Chemistry. 49, 6, p. 2077-2087 11 p.

Nystatin biosynthesis and transport: nysH and nysG genes encoding a putative ABC transporter system in Streptomyces noursei ATCC 11455 are required for efficient conversion of 10-deoxynystatin to nystatin

Sletta, H., Borgos, S., Bruheim, P., Sekurova, O., Grasdalen, H., Aune, R., Ellingsen, T. & Zotchev, S., Nov 2005, In: Antimicrobial Agents and Chemotherapy. 49, 11, p. 4576-4583 8 p.

An unexpected role for the putative 4 '-phosphopantetheinyl transferase-encoding gene nysF in the regulation of nystatin blosynthesis in Streptomyces noursei ATCC 11455

Volokhan, O., Sletta, H., Sekurova, O., Ellingsen, T. & Zotchev, S., 1 Aug 2005, In: FEMS Microbiology Letters. 249, 1, p. 57-64 8 p.

Biosynthesis of the polyene macrolide antibiotic nystatin in Streptomyces noursei

Fjaervik, E. & Zotchev, S., Jun 2005, In: Applied Microbiology and Biotechnology. 67, 4, p. 436-443 8 p.

Comparative analysis of in vitro antifungal activity and in vivo acute toxicity of the nystatin analogue S44HP produced via genetic manipulation

Treshchalin, I. D., Sletta, H., Borgos, S. E. F., Pereverzeva, E. R., Voeikova, T. A., Ellingsen, T. E. & Zotchev, S. B., 2005, In: Antibiotiki i khimioterapii︠a︡. 50, 7, p. 18-22 5 p.

Сравнительный анализ противогрибковой активности in vitro и острой токсичности in vivo аналога нистатина S44HP, полученного методом генной инженерии

Treshchalin, I. D., Sletta, H., Borgos, S. E., Pereverzeva, E. P., Voeĭkova, T. A., Ellingsen, T. E. & Zotchev, S. B., 2005, In: Antibiotiki i khimioterapii︠a︡. 50, 7, p. 18-22 5 p.

Chemical diversity of polyene macrolides produced by Streptomyces noursei ATCC 11455 and recombinant strain ERD44 with genetically altered polyketide synthase NysC

Bruheim, P., Borgos, S., Tsan, P., Sletta, H., Ellingsen, T., Lancelin, J. & Zotchev, S., Nov 2004, In: Antimicrobial Agents and Chemotherapy. 48, 11, p. 4120-4129 10 p.

Biosynthesis of deoxyaminosugars in antibiotic-producing bacteria

Nedal, A. & Zotchev, S., Mar 2004, In: Applied Microbiology and Biotechnology. 64, 1, p. 7-15 9 p.

In vivo analysis of the regulatory genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455 reveals their differential control over antibiotic biosynthesis

Sekurova, O., Brautaset, T., Sletta, H., Borgos, S., Jakobsen, O., Ellingsen, T., Strom, A., Valla, S. & Zotchev, S., Mar 2004, In: Journal of Bacteriology. 186, 5, p. 1345-1354 10 p.

Polyene antibiotic biosynthesis gene clusters

Aparicio, J., Caffrey, P., Gil, J. & Zotchev, S., May 2003, In: Applied Microbiology and Biotechnology. 61, 3, p. 179-188 10 p.

Site-specific mutagenesis and domain substitutions in the loading module of the nystatin polyketide synthase, and their effects on nystatin biosynthesis in Streptomyces noursei

Brautaset, T., Borgos, S., Sletta, H., Ellingsen, T. & Zotchev, S., 25 Apr 2003, In: Journal of Biological Chemistry. 278, 17, p. 14913-14919 7 p.

Bioconversion of aromatics in light gas oil in a continuous bioreactor system.

Kotlar, H., Grande, K., Rasmussen, K., Ramstad, M., Markussen, S., Winnberg, A., Zotchev, S. & Gimmestad, M., Mar 2003, In: American Chemical Society. Abstracts of Papers (at the National Meeting). 225, p. U851-U851 1 p.

Bioconversion of aromatics in light gas oil (LGO) in a continuous bioreactor system.

Kotlar, H., Rasmussen, K., Markussen, S., Winnberg, A., Zotchev, S. & Gimmestad, M., Mar 2003, In: American Chemical Society. Abstracts of Papers (at the National Meeting). 225, p. U425-U425 1 p.

Polyene macrolide antibiotics and their applications in human therapy

Zotchev, S., Feb 2003, In: Current Medicinal Chemistry. 10, 3, p. 211-223 13 p.

Hexaene derivatives of nystatin produced as a result of an induced rearrangement within the nysC polyketide synthase gene in S. noursei ATCC 11455

Brautaset, T., Bruheim, P., Sletta, H., Hagen, L., Ellingsen, T., Strom, A., Valla, S. & Zotchev, S., Mar 2002, In: Chemistry & Biology. 9, 3, p. 367-373 7 p., PII S1074-5521(02)00108-4.

Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: Analysis of the gene cluster and deduction of the biosynthetic pathway

Brautaset, T., Sekurova, O. N., Sletta, H., Ellingsen, T. E., Strøm, A. R., Valla, S. & Zotchev, S. B., 1 Jun 2000, In: Chemistry and Biology. 7, 6, p. 395-403 9 p.

Identification of a methyl-specific restriction system mediated by a conjugative element from Streptomyces bambergiensis

Zotchev, S. B., Schrempf, H. & Hutchinson, C. R., 1995, In: Journal of Bacteriology. 177, 16, p. 4809-4812 4 p.

The linear Streptomyces plasmid pBL1: analyses of transfer functions

Zotchev, S. B. & Schrempf, H., Feb 1994, In: Molecular and general genetics : MGG. 242, 4, p. 374-382 9 p.

Obnaruzhenie gigantskikh plazmid v shtammakh Streptomyces bambergiensis.

Zotchev, S. B., Beritashvili, D. R., Rozanfel'd, S. M., Zhdanov, V. G. & Orekhov, A. V., 1990, In: Doklady Akademii nauk SSSR. 313, 1, p. 203-206 4 p.

Transformatsiia protoplastov Streptomyces bambergiensis S712 plazmidnoĭ DNK

Zotchev, S. B., Rozenfel'd, S. M. & Zhdanov, V. G., Mar 1988, In: Antibiotiki i khimioterapii︠a︡. 33, 3, p. 200-3 4 p.