Research

Thesis title: "Extracellular Vesicles Mediated Muscle–Immune Crosstalk: Effects of Exercise Modalities and Aging"

Thesis outline: This PhD project investigates the kinetics, dynamics, and functional role of extracellular vesicles (EVs) in exercise-induced intercellular communication, with a particular focus on the interaction between muscle and immune cells. The study explores how exercise modalities, fitness level, age, and other individual factors influence EV release and cargo composition.

By systematically characterizing EVs and their molecular content, the research aims to uncover the physiological relevance of EVs in response to physical activity. Special attention is given to the aging process, with the goal of understanding how exercise modifies EV-mediated signaling pathways over the lifespan. This sports science approach will generate mechanistic insights into how physical activity contributes to healthy aging.

Given their role in mediating intercellular communication, EVs serve as both markers and modulators of biological processes. The project will evaluate how age-related changes in EV cargo reflect cellular health and how exercise might counteract these alterations. Ultimately, the findings aim to identify exercise strategies that best support muscle–immune crosstalk and extend healthspan through improved understanding of EV function.

Funding: University Assistant (predoctoral)

Supervisor: Barbara Wessner, Advisor: Robert Csapo, Andreas Spittler (Medical University of Vienna)

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